The effect of transdermal glyceryl trinitrate on 24h ambulatory blood pressure in acute/subacute stroke

Background High blood pressure is a common complication in acute stroke and is associated with a poor outcome. Aims This study assesses the effects of transdermal glyceryl trinitrate on 24h ambulatory blood pressure in patients with recent stroke. Methods One hundred and seven patients with acute is...

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Bibliographic Details
Published in:International journal of stroke 2011-08, Vol.6 (4), p.290-294
Main Authors: Geeganage, Chamila M, Bath, Andrew JG, Bath, Philip MW
Format: Article
Language:English
Subjects:
Blood pressure
Clinical trials
Data processing
Daytime
Heart rate
Hypertension
Stroke
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Summary:Background High blood pressure is a common complication in acute stroke and is associated with a poor outcome. Aims This study assesses the effects of transdermal glyceryl trinitrate on 24h ambulatory blood pressure in patients with recent stroke. Methods One hundred and seven patients with acute ischaemic or haemorrhagic stroke were included. The patients had been enrolled in one of two trials of transdermal glyceryl trinitrate (5mg daily) or placebo/control, and underwent 24h ambulatory blood pressure monitoring (56 glyceryl trinitrate, 51 control). Ambulatory blood pressure data were analysed using area under the curve for the entire 24h, and day and night periods. Nocturnal dipping was defined as a decline in systolic blood pressure >10%. Comparisons of blood pressure between groups were performed by analysis of covariance (ANCOVA) with adjustments for trial and baseline measure. Results In comparison with control, glyceryl trinitrate significantly lowered 24h blood pressure (systolic blood pressure/diastolic blood pressure 9.4/4.8mmHg, P
ISSN:1747-4930
1747-4949
DOI:10.1111/j.1747-4949.2010.00566.x