Neuroschistosomiasis: clinical symptoms and pathogenesis

Summary Neuroschistosomiasis, referring to schistosomal involvement of the CNS, when symptomatic, is a severe disorder in which prognosis depends largely on early diagnosis and treatment. It is an underdiagnosed disorder, but has been increasingly reported in populations in endemic areas and in tour...

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Bibliographic Details
Published in:Lancet neurology 2011-09, Vol.10 (9), p.853-864
Main Authors: Ferrari, Teresa Cristina A, Prof, Moreira, Paulo Roberto R, MD
Format: Article
Language:English
Subjects:
Animals
Asymptomatic
Brain
Central nervous system diseases
Eggs
Endemic Diseases
Granulomas
Humans
Infection
Infections
Neurology
Neuroschistosomiasis - diagnosis
Neuroschistosomiasis - epidemiology
Neuroschistosomiasis - etiology
Parasites
Parasitic diseases
Pathogenesis
Prognosis
Schistosoma haematobium
Schistosoma japonicum
Schistosoma mansoni
Schistosomiasis
Spinal cord
Travel - trends
Urogenital system
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Summary:Summary Neuroschistosomiasis, referring to schistosomal involvement of the CNS, when symptomatic, is a severe disorder in which prognosis depends largely on early diagnosis and treatment. It is an underdiagnosed disorder, but has been increasingly reported in populations in endemic areas and in tourists. CNS involvement can occur at any time during schistosomal infection. Both the brain and the spinal cord can be affected. Schistosoma mansoni and Schistosoma haematobium usually cause myelopathy, whereas Schistosoma japonicum usually causes encephalic disease. There are substantial differences in the pathogenesis, clinical presentation, and outcome of the neurological disorder, depending on the phase and clinical form of schistosomiasis in which it occurs.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(11)70170-3