Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

TiO2 films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO2 films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in a...

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Bibliographic Details
Published in:Biotechnology journal 2011-02, Vol.6 (2), p.213-223
Main Authors: Hyde, G. Kevin, Stewart, S. Michael, Scarel, Giovanna, Parsons, Gregory N., Shih, Chun-Che, Shih, Chun-Ming, Lin, Shing-Jong, Su, Yea-Yang, Monteiro-Riviere, Nancy A., Narayan, Roger J.
Format: Article
Language:English
Subjects:
Biomaterials
Cell Survival - physiology
Cellulose
Cellulose - analogs & derivatives
Cellulose - chemistry
Cellulose - pharmacology
Hemocompatibility
Hemostasis - drug effects
Hemostatic agent
Humans
Microscopy, Electron, Scanning
Platelet-Rich Plasma - drug effects
Spectroscopy, Fourier Transform Infrared
Titanium - chemistry
Titanium oxide
Wettability
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Summary:TiO2 films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO2 films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO2 films were shown to profoundly alter the water contact angle values of cellulose in a manner dependent upon processing characteristics. Higher amounts of protein adsorption indicated by blurry areas on images generated by scanning electron microscopy were noted on TiO2‐coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood‐contacting biomaterials.
ISSN:1860-6768
1860-7314
1860-7314
DOI:10.1002/biot.201000342