Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population

• Published in: Human immunology 2011-07, Vol.72 (7), p.566-570
• Main Authors: Mitsunaga, Shigeki, Homma, Yasuhiko, Narita, Akira, Kashiwase, Koichi, Okudaira, Yuko, Shiina, Yutaka, Inoue, Ituro, Inoko, Hidetoshi
• Format: Article
• Language: English
• Subjects: Alleles; Allergy and Immunology; Asian Continental Ancestry Group - genetics; Association; Biochemical trait; Cholesterol; Fasting; Female; Genetic Association Studies; Glucose; Histocompatibility antigen HLA; Histocompatibility Testing; HLA; HLA Antigens - genetics; Hospitals; Humans; Lipoproteins; Lipoproteins (low density); Male; Metabolic Networks and Pathways - genetics; Middle Aged; Population genetics; Quantitative Trait Loci - genetics; Statistics; Triglycerides; Uric acid
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2011.03.011

Abstract We analyzed genetic associations among 7 biochemical traits (fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, triglyceride, and uric acid) and 6 HLA loci using 1,616 individuals who visited the Health Evaluation and Promotion Center at Tokai University Hospital. Significant differences between the individuals carrying particular HLA alleles and those not carrying the alleles in certain biochemical traits were observed by Mann–Whitney U test. In female subjects, DPB1*03:01 was significantly associated with HbA1c ( p = 0.0000665), and DRB1*14:03 was associated with total cholesterol concentration ( p = 0.0015). In male subjects, C*14:02 demonstrated significant associations with fasting plasma glucose with p values of 0.0041. By contrast, Fisher's exact test indicated that female DRB1*14:03 was associated with a high concentration of total cholesterol ( p = 000323, odds ratio [OR] = 4.32, 95% confidence interval [95% CI] = 1.83–10.36), whereas female DPB1*02:01 had a protective effect against a high concentration of LDL cholesterol ( p =0.0043, OR = 0.41, 95% CI = 0.19–0.79). These associations have a statistical power of more than 0.8 and still retain significance after Bonferroni correction.