Correlation between rate of bony ingrowth to stainless steel, pure titanium, and titanium alloy implants in vivo and formation of hydroxyapetite on their surfaces in vitro

The rate of bony ingrowth to identical metal implants made of either pure titanium (cpTi), titanium alloy (Ti‐6Al‐4V), or stainless steel 316L (SS) inserted to the medullar canal of the femur in rats was investigated. The kinetics of spontaneous deposition of hydroxyapatite (HA) globules on the afor...

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Published in:Journal of biomedical materials research. Part A 2009-12, Vol.91A (4), p.1006-1009
Main Authors: Oron, A., Agar, G., Oron, U., Stein, A.
Format: Article
Language:English
Subjects:
Austenitic stainless steels
Biocompatibility
Biomedical materials
bone growth
Bones
Heat resistant steels
Hydroxyapatite
in vitro
In vitro testing
in vivo
metal implants
Protective coatings
simulated body fluid
Surgical implants
Titanium base alloys
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Summary:The rate of bony ingrowth to identical metal implants made of either pure titanium (cpTi), titanium alloy (Ti‐6Al‐4V), or stainless steel 316L (SS) inserted to the medullar canal of the femur in rats was investigated. The kinetics of spontaneous deposition of hydroxyapatite (HA) globules on the aforementioned metals in vitro during incubation in simulated body fluid (SBF) was also studied. It was found that the rate of increased bonding strength between the cpTi implants and the host bone was the highest, whereas around the SS implants it was the slowest. At 10 days postimplant insertion, the shear strength of the cpTi implants was 2.2‐ and 4‐fold significantly higher than for the Ti‐6Al‐4V and the SS implants, respectively. Spontaneous formation of the HA globules on the cpTi and Ti‐6Al‐4V implants that were incubated in the SBF was observed as early as 6 and 10 days after incubation in SBF, respectively, whereas on SS implants, deposition of HA was evident only after 2 weeks of in vitro incubation in SBF. It is concluded that the chemical surface characteristics and the biocompatibility of the implants probably play a key role in the process of bone growth next to them, during the formation of bone in vivo. The rate of bony ingrowth to various metal implants alloys inserted into the medullar canal of rats correlates well with the induction of apatite formation on them during incubation in vitro with SBF. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32299