Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing

Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections....

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Bibliographic Details
Published in:Aquaculture 2011-07, Vol.317 (1), p.53-57
Main Authors: Natrah, F.M.I., Kenmegne, Mireille Mardel, Wiyoto, Wiyoto, Sorgeloos, Patrick, Bossier, Peter, Defoirdt, Tom
Format: Article
Language:English
Subjects:
Algae
Animal aquaculture
Animal productions
aquaculture
bacteria
bacterial infections
Biological and medical sciences
biological control
bioluminescence
Chlorella saccharophila
Chromobacterium violaceum
Escherichia coli
Freshwater
Fundamental and applied biological sciences. Psychology
gene expression
General aspects
lactones
Luminescent vibrios
Micro-algae
pathogens
phenotype
Quorum sensing
Quorum sensing interference
Vibrio harveyi
virulence
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Summary:Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains.
ISSN:0044-8486
1873-5622
DOI:10.1016/j.aquaculture.2011.04.038