The Evolution of Coreceptor Tropism in HIV-infected Patients Interrupting Suppressive Antiretroviral Therapy

CCR5 antagonists may provide a well-tolerated switch option for patients experiencing tolerability or toxicity of their antiretroviral regimen. We analyzed stored samples from patients undergoing planned treatment interruptions for reasons other than virological failure, in order to analyze tropism...

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Bibliographic Details
Published in:Clinical infectious diseases 2011-03, Vol.52 (5), p.671-673
Main Authors: Waters, Laura J., Scourfield, Andrew T., Marcano, Marie, Gazzard, Brian G., Bower, Mark, Nelson, Mark, Stebbing, Justin
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-HIV Agents - administration & dosage
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Antiretrovirals
Antiviral agents
Arts
Biological and medical sciences
BRIEF REPORT
Drug therapy
Female
HIV
HIV - pathogenicity
HIV 1
HIV Fusion Inhibitors - administration & dosage
HIV Infections - drug therapy
HIV Infections - virology
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Medical treatment
Pharmacology. Drug treatments
Pregnancy
Proteins
Ribonucleic acid
RNA
Toxicity
Tropisms
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral load
Viral Tropism
Virology
Viruses
Withholding Treatment
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Description
Summary:CCR5 antagonists may provide a well-tolerated switch option for patients experiencing tolerability or toxicity of their antiretroviral regimen. We analyzed stored samples from patients undergoing planned treatment interruptions for reasons other than virological failure, in order to analyze tropism evolution during fully suppressive antiretroviral therapy (ART). Two of 37 patients showed evidence of switching. Tropism switching after suppressive ART was uncommon in this cohort. Pretreatment human immunodeficiency virus (HIV) RNA tropism testing may help guide the switch to CCR5 antagonists in patients with undetectable HIV RNA.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciq198