Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing

Abstract Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to...

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Published in:Nanomedicine 2011-08, Vol.7 (4), p.497-504
Main Authors: Kwan, Karen H.L., BSc, Liu, Xuelai, MD, To, Michael K.T., MBBS, Yeung, Kelvin W.K., PhD, Ho, Chi-ming, PhD, Wong, Kenneth K.Y., MD, PhD
Format: Article
Language:English
Subjects:
Animals
Collagen - chemistry
Collagen - metabolism
Collagen organization
Healing
Internal Medicine
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Mice
Mice, Inbred C57BL
Microscopy, Electron, Scanning
Silver - chemistry
Silver nanoparticles
Skin - drug effects
Skin - metabolism
Skin - ultrastructure
Tensile Strength
Wound Healing - drug effects
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Summary:Abstract Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. From the Clinical Editor The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. These nanoparticles improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2011.01.003