Oropharyngeal angioneurotic edema due to recombinant tissue plasminogen activator following massive pulmonary thromboembolism

Although hypersensitivity reactions secondary to recombinant tissue plasminogen activator (rtPA) are rarely encountered, they may have important consequences. In this case presentation, oropharyngeal angioneurotic edema due to rtPA following pulmonary thromboembolism is presented. On the 4th hour of...

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Bibliographic Details
Published in:International immunopharmacology 2011-09, Vol.11 (9), p.1384-1385
Main Authors: Ekmekçi, Perihan, Bengisun, Züleyha Kazak, Kazbek, Baturay Kansu, Akmansu, Halit, Beriat, Güçlü Kaan, Süer, Arif Hikmet
Format: Article
Language:English
Subjects:
Aged
Allergic diseases
Anaphylactoid reaction
Angioedema - chemically induced
Angioedema - drug therapy
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Humans
Immunopathology
Medical sciences
Oropharyngeal edema
Oropharynx - pathology
Pharmacology. Drug treatments
Pneumology
Pulmonary embolism
Pulmonary Embolism - drug therapy
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Recombinant Proteins - adverse effects
Recombinant Proteins - therapeutic use
rTPA
Skin allergic diseases. Stinging insect allergies
Tissue Plasminogen Activator - adverse effects
Tissue Plasminogen Activator - therapeutic use
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Summary:Although hypersensitivity reactions secondary to recombinant tissue plasminogen activator (rtPA) are rarely encountered, they may have important consequences. In this case presentation, oropharyngeal angioneurotic edema due to rtPA following pulmonary thromboembolism is presented. On the 4th hour of initiation of treatment, throat pain, laryngeal stridor and expansive edema in the neck ensued, upon which the patient was intubated and mechanically ventilated. The patient was extubated after her findings showed a remission on the 48th hour of his inotropic, antihistaminic and intravenous corticosteroid therapy.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2011.04.020