An insect growth inhibitor – lufenuron – enhances albendazole activity against hydatid cyst

The aim of this work was to evaluate the potential of lufenuron, a benzylphenylurea with ability to interfere with the formation of insect exoskeleton, as a therapeutic drug for larval echinococcosis (hydatid disease). For this purpose lufenuron, alone or in combination with albendazole, was adminis...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary parasitology 2011-09, Vol.181 (2-4), p.341-344
Main Authors: Breijo, Martín, Isnardi, Fernanda, Brauer, Mónica, Schenker, Rudolf, Ferrari, Mariana, Ferreira, Ana M.
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - administration & dosage
Albendazole - therapeutic use
Animals
Anthelmintics - administration & dosage
Anthelmintics - therapeutic use
Benzamides - administration & dosage
Benzamides - therapeutic use
Chemotherapy
Drug Synergism
Drug Therapy, Combination
Echinococcosis - drug therapy
Hydatid disease
Lufenuron
Mice
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this work was to evaluate the potential of lufenuron, a benzylphenylurea with ability to interfere with the formation of insect exoskeleton, as a therapeutic drug for larval echinococcosis (hydatid disease). For this purpose lufenuron, alone or in combination with albendazole, was administered to CD1 mice bearing Echinococcus granulosus hydatid cysts in the peritoneal cavity. Neither of the drugs alone was able to exert parasiticidal effects. However, in combination with albendazole, lufenuron reduced the growth of cysts (30–40% in cyst diameter respect to control, p
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2011.04.011