Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone

ABSTRACT Purpose To develop polymer micelles for the tunable release of Dexamethasone (DEX) in tumors. Methods DEX was conjugated to poly(ethylene glycol)-poly(aspartate) block copolymers using hydrazone, ester, or hydrazone-ester dual linkers. Ketonic acids containing 3, 4, and 5 methylene groups w...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical research 2011-10, Vol.28 (10), p.2435-2446
Main Authors: Howard, Melissa D., Ponta, Andrei, Eckman, Allison, Jay, Michael, Bae, Younsoo
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Carboxylesterase - metabolism
Dexamethasone - chemistry
Drug Carriers - chemistry
Drug delivery systems
Drug Delivery Systems - methods
Esters - chemistry
General pharmacology
Hydrazones - chemistry
Hydrogen-Ion Concentration
Medical Law
Medical sciences
Micelles
Pharmaceutical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Research Paper
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Purpose To develop polymer micelles for the tunable release of Dexamethasone (DEX) in tumors. Methods DEX was conjugated to poly(ethylene glycol)-poly(aspartate) block copolymers using hydrazone, ester, or hydrazone-ester dual linkers. Ketonic acids containing 3, 4, and 5 methylene groups were used as spacers to separate the dual linkers. Polymer micelles from the DEX-conjugated polymers were tested for drug release at different pH values and carboxylesterase activity levels. Results DLS measurements and 1 H-NMR analysis confirmed all DEX-loaded micelles were
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-011-0470-1