The steroid metabolome in lamotrigine-treated women with epilepsy

[Display omitted] ► Evaluation of circulating steroids in fertile lamotrigine-treated women with epilepsy. ► Patients exhibit higher levels of 3α-hydroxy-5α/β-reduced androstanes. ► Patients have increased activity of 17α-hydroxylase/17,20 lyase in Δ5-steroids. ► Patients show increased levels of st...

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Published in:Steroids 2011-11, Vol.76 (12), p.1351-1357
Main Authors: Hill, Martin, Vrbíková, Jana, Zárubová, Jana, Kancheva, Radmila, Velíková, Marta, Kancheva, Lyudmila, Kubátová, Jana, Dušková, Michaela, Marusič, Petr, Pařízek, Antonín, Stárka, Luboslav
Format: Article
Language:English
Subjects:
17-alpha-Hydroxypregnenolone - blood
Adult
Androstanes
Androstanes - blood
Androstanes - metabolism
Androstanols - blood
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Biological and medical sciences
Epilepsy
Epilepsy - drug therapy
Epilepsy - metabolism
Female
Fundamental and applied biological sciences. Psychology
gas chromatography–mass spectrometry
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Lamotrigine
Medical sciences
Metabolome
Nervous system (semeiology, syndromes)
Neuroactive steroids
Neurology
Pregnanolone isomers
Steroid 17-alpha-Hydroxylase - blood
Triazines - adverse effects
Triazines - therapeutic use
Vertebrates: endocrinology
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Summary:[Display omitted] ► Evaluation of circulating steroids in fertile lamotrigine-treated women with epilepsy. ► Patients exhibit higher levels of 3α-hydroxy-5α/β-reduced androstanes. ► Patients have increased activity of 17α-hydroxylase/17,20 lyase in Δ5-steroids. ► Patients show increased levels of steroid polar conjugates. Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect on the levels of other neuroactive steroid metabolites such as 3a-hydroxy-5a/b-reduced androstanes. To evaluate steroid alterations in women with epilepsy (WWE) on lamotrigine monotherapy. Eleven WWE and 11 age-matched healthy women underwent blood sampling in both phases of their menstrual cycles (MCs). The steroid metabolome, which included 30 unconjugated steroids, 17 steroid polar conjugates, gonadotropins, and sex hormone-binding globulin (SHBG), was measured using gas chromatography–mass spectrometry (GC–MS) and radioimmunoassay (RIA). WWE had lower cortisol levels (status p
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2011.07.002