Clinical Tests of Therapeutical Failures Based on Mathematical Modeling of the HIV Infection

Clinical tests which are displayed are based on a system-theoretic approach for an early diagnosis of the immunological and virological failure of HIV patients. Mathematical characterizations of therapeutical failures are presented in this paper. Mathematical modeling is used for individual patients...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on automatic control 2008-01, Vol.53 (Special Issue), p.230-241
Main Authors: Ouattara, Djomangan Adama, Mhawej, Marie-JosÉ, Moog, Claude H.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
clinical trial
Clinical trials
Diagnosis
Discretization
Drugs
early diagnosis
Evolution
Failure
HIV
Human immunodeficiency virus
identifiability
Immune system
Invariants
Kinetic theory
Mathematical model
Mathematical models
Medical treatment
nonlinear systems
Parameter estimation
Patients
System testing
therapeutical failures
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clinical tests which are displayed are based on a system-theoretic approach for an early diagnosis of the immunological and virological failure of HIV patients. Mathematical characterizations of therapeutical failures are presented in this paper. Mathematical modeling is used for individual patients to help for an early diagnosis of the evolution of the infection. The feasibility of the method is depicted on some patients who start highly active antiretroviral therapy (HAART). The identifiability of the continuous-time models which are used is proved, and it is shown to be invariant under discretization.
ISSN:0018-9286
1558-2523
DOI:10.1109/TAC.2007.911332