Quantitative depth analysis of optic nerve head using stereo retinal fundus image pair

Depth analysis of the optic nerve head (ONH) in the retinal fundus is important for the early detection of glaucoma. In this study, we investigate an automatic reconstruction method for the quantitative depth measurement of the ONH from a stereo retinal fundus image pair. We propose a technique to o...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2008-11, Vol.13 (6), p.064026-0640210
Main Authors: Nakagawa, Toshiaki, Suzuki, Takayoshi, Hayashi, Yoshinori, Mizukusa, Yutaka, Hatanaka, Yuji, Ishida, Kyoko, Hara, Takeshi, Fujita, Hiroshi, Yamamoto, Tetsuya
Format: Article
Language:English
Subjects:
Algorithms
Artificial Intelligence
Confocal
Depth measurement
Eyes
Glaucoma
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Mathematical analysis
Microscopy, Confocal - methods
Nerves
Optic Disk - cytology
optic nerve head
Pattern Recognition, Automated - methods
Photogrammetry - methods
Reproducibility of Results
retinal fundus image
Retinoscopy - methods
Sensitivity and Specificity
stereo image
Subtraction Technique
Tomography, Optical - methods
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Summary:Depth analysis of the optic nerve head (ONH) in the retinal fundus is important for the early detection of glaucoma. In this study, we investigate an automatic reconstruction method for the quantitative depth measurement of the ONH from a stereo retinal fundus image pair. We propose a technique to obtain the depth value from the stereo retinal fundus image pair, which mainly consists of five steps: 1. cutout of the ONH region from the stereo retinal fundus image pair, 2. registration of the stereo image pair, 3. disparity measurement, 4. noise reduction, and 5. quantitative depth calculation. Depth measurements of 12 normal eyes are performed using the stereo fundus camera and the Heidelberg Retina Tomograph (HRT), which is a confocal laser-scanning microscope. The depth values of the ONH obtained from the stereo retinal fundus image pair were in good accordance with the value obtained using HRT . These results indicate that our proposed method could be a useful and easy-to-handle tool for assessing the cup depth of the ONH in routine diagnosis as well as in glaucoma screening.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3041711