Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue

Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized-a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanoc...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2009-03, Vol.14 (2), p.024042-024049
Main Authors: Zhang, Kai, Zhang, Wenkai, Yang, Chia-Yi, Yang, Haw
Format: Article
Language:English
Subjects:
Aged
Biomedical materials
cell-extracellular matrix interaction
Character recognition
Computer-Aided Design
Culture
Dermoscopy - instrumentation
Equipment Design
Equipment Failure Analysis
Female
Human
Humans
In vivo testing
In vivo tests
Melanoma - pathology
Microscopy, Fluorescence, Multiphoton - instrumentation
Microscopy, Polarization - instrumentation
optical microscopy
Recognition
Reproducibility of Results
second harmonic generation (SHG)
Sensitivity and Specificity
skin cancer
Skin Neoplasms - pathology
Staining and Labeling
Surgical implants
two-photon excited fluorescence
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Description
Summary:Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized-a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanocytes but has not been demonstrated in clinical instances. The results thus provide snapshots of invading melanoma cells in their native environment and suggest a practical means of connecting laboratory studies to processes.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3120491