Biological reactivity of nanoparticles: mosaics from optical microscopy videos of giant lipid vesicles

Emerging fields such as nanomedicine and nanotoxicology, demand new information on the effects of nanoparticles on biological membranes and lipid vesicles are suitable as an experimental model for bio-nano interaction studies. This paper describes image processing algorithms which stitch video seque...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2011-02, Vol.16 (2), p.026003-026003
Main Authors: Zupanc, Jernej, Dobnikar, Andrej, Drobne, Damjana, Valant, Janez, Erdogmus, Deniz, Bas, Erhan
Format: Article
Language:English
Subjects:
Biological
Biomimetic Materials - chemistry
Lipids
Materials Testing - methods
Mathematical models
Microscopy, Video - methods
Mosaics
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Unilamellar Liposomes - chemistry
Vesicles
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Summary:Emerging fields such as nanomedicine and nanotoxicology, demand new information on the effects of nanoparticles on biological membranes and lipid vesicles are suitable as an experimental model for bio-nano interaction studies. This paper describes image processing algorithms which stitch video sequences into mosaics and recording the shapes of thousands of lipid vesicles, which were used to assess the effect of CoFe O nanoparticles on the population of 1-palmitoyl-2-oleoyl- -glycero-3-phosphatidylcholine lipid vesicles. The applicability of this methodology for assessing the potential of engineered nanoparticles to affect morphological properties of lipid membranes is discussed.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3533319