Coagulation dynamics of a blood sample by multiple scattering analysis

We report a new technique to measure coagulation dynamics on whole-blood samples. The method relies on the analysis of the speckle figure resulting from a whole-blood sample mixed with coagulation reagent and introduced in a thin chamber illuminated with a coherent light. A dynamic study of the spec...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2011-05, Vol.16 (5), p.057001-057001
Main Authors: Faivre, Magalie, Cosnier, Marie-Line, Pouteau, Patrick, Pelti, Philippe, Planat-Chrtien, Anne, Cubizolles, Myriam, Nougier, Christophe, Negrier, Claude
Format: Article
Language:English
Subjects:
Blood
Blood Coagulation - physiology
Chambers
Coagulation
Coherent light
Dynamic tests
Dynamics
Equipment Design
Equipment Failure Analysis
Humans
Lasers
Light
Medical
Photometry - instrumentation
Refractometry - instrumentation
Scattering
Scattering, Radiation
Whole Blood Coagulation Time - instrumentation
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Summary:We report a new technique to measure coagulation dynamics on whole-blood samples. The method relies on the analysis of the speckle figure resulting from a whole-blood sample mixed with coagulation reagent and introduced in a thin chamber illuminated with a coherent light. A dynamic study of the speckle reveals a typical behavior due to coagulation. We compare our measured coagulation times to a reference method obtained in a medical laboratory.
ISSN:1083-3668
1560-2281
1560-2281
DOI:10.1117/1.3573813