Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy

One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were perf...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2009-01, Vol.14 (1), p.014014-014016
Main Authors: Pichler, Gerhard, Grossauer, Karin, Peichl, Elisabeth, Gaster, Andrea, Berghold, Andrea, Schwantzer, Gerold, Zotter, Heinz, Mu¨ller, Wilhelm, Urlesberger, Berndt
Format: Article
Language:English
Subjects:
Algorithms
Criteria
Diagnosis, Computer-Assisted - methods
Female
Humans
Infant, Newborn
Male
Mathematical analysis
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
near-infrared spectroscopy
Occlusion
Oximetry - methods
Oxygen - analysis
Oxygenation
peripheral muscle
quality criteria
Reproducibility
Reproducibility of Results
Sensitivity and Specificity
Spectroscopy, Near-Infrared - methods
Standard deviation
Vanadium oxides
Variance
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Summary:One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were performed on the calf. During five "reapplication" periods (of NIRS optodes), five "measurements" (venous occlusions) were performed. Tissue oxygenation index (TOI), mixed venous oxygenation (SvO2), fractional oxygen extraction (FOE), hemoglobin flow (Hbflow), oxygen delivery (DO2), and oxygen consumption (VO2) were assessed. Measurements with linear changes during venous occlusions were included for further analysis (first quality criterion: ). The second quality criterion was the equation . Variance components and mean standard deviations were analyzed after introduction of the quality criteria. Variance components of reapplication and measurement decreased after introduction of the second quality criterion (TOI: 46.6-35.0 , SvO2: 76.8-38.2 , FOE: 73.1-37.5 , Hbflow: 70.3-51.9 , DO2: 71.5-52.7 , and VO2: 70.9-63.8 ). Mean standard deviations of TOI ( to ), SvO2 ( to ), FOE ( to ), Hbflow ( to ), and DO2 ( to ) decreased significantly, too. Only 12 of measurements fulfilled both quality criteria. With the introduction of two quality criteria, test-retest variability of peripheral NIRS measurements decreased significantly and reproducibility increased significantly.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3076193