Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions

The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy duri...

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Bibliographic Details
Published in:Journal of biomedical optics 2009-01, Vol.14 (1), p.014028-014028
Main Authors: Lin, Wei-Chiang, Sandberg, David I, Bhatia, Sanjiv, Johnson, Mahlon, Morrison, Glenn, Ragheb, John
Format: Article
Language:English
Subjects:
Adolescent
Brain
Brain Chemistry
Brain Neoplasms - chemistry
Brain Neoplasms - complications
Brain Neoplasms - diagnosis
Child
Child, Preschool
Diagnosis, Computer-Assisted - methods
Diagnosis, Differential
Diffusion
Epilepsy - complications
Epilepsy - diagnosis
Female
Fluorescence
Humans
In vitro testing
Infant
Infant, Newborn
Male
Patients
Reflectance
Reproducibility of Results
Sensitivity and Specificity
Spectra
Spectrometry, Fluorescence - methods
Spectroscopy
Young Adult
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Summary:The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy during surgical resection of epileptogenic cerebral cortex. Fluorescence spectra are measured at excitations of 337, 360, and 440 nm; diffuse reflectance spectra are measured between 400 and 900 nm from each specimen. Pathological analysis is performed to classify abnormalities in brain specimens, and its findings are correlated with spectral data. Statistically significant differences (p
ISSN:1083-3668
DOI:10.1117/1.3080144