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Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions
The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy duri...
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| Published in: | Journal of biomedical optics 2009-01, Vol.14 (1), p.014028-014028 |
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| cites | cdi_FETCH-LOGICAL-c416t-214abbbbcb74f00d3ab4b3df65f2ab3687dbc6cd310014b181d43831750cdc983 |
| container_end_page | 014028 |
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| container_title | Journal of biomedical optics |
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| creator | Lin, Wei-Chiang Sandberg, David I Bhatia, Sanjiv Johnson, Mahlon Morrison, Glenn Ragheb, John |
| description | The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy during surgical resection of epileptogenic cerebral cortex. Fluorescence spectra are measured at excitations of 337, 360, and 440 nm; diffuse reflectance spectra are measured between 400 and 900 nm from each specimen. Pathological analysis is performed to classify abnormalities in brain specimens, and its findings are correlated with spectral data. Statistically significant differences (p |
| doi_str_mv | 10.1117/1.3080144 |
| format | article |
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Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy during surgical resection of epileptogenic cerebral cortex. Fluorescence spectra are measured at excitations of 337, 360, and 440 nm; diffuse reflectance spectra are measured between 400 and 900 nm from each specimen. Pathological analysis is performed to classify abnormalities in brain specimens, and its findings are correlated with spectral data. Statistically significant differences (p<0.01) are found for both raw and normalized diffuse reflectance and fluorescence spectra between 1. neoplastic brain and normal gray matter, 2. epileptogenic brain and normal gray matter, and 3. neoplastic brain and normal white matter. However, no distinct spectral features are identified that effectively separate epileptogenic brain from normal white matter. The outcomes of the study suggest that certain unique compositional and structural characteristics of pediatric neoplastic and epileptogenic brain can be detected using optical spectroscopy in vitro.</description><identifier>ISSN: 1083-3668</identifier><identifier>DOI: 10.1117/1.3080144</identifier><identifier>PMID: 19256716</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Brain ; Brain Chemistry ; Brain Neoplasms - chemistry ; Brain Neoplasms - complications ; Brain Neoplasms - diagnosis ; Child ; Child, Preschool ; Diagnosis, Computer-Assisted - methods ; Diagnosis, Differential ; Diffusion ; Epilepsy - complications ; Epilepsy - diagnosis ; Female ; Fluorescence ; Humans ; In vitro testing ; Infant ; Infant, Newborn ; Male ; Patients ; Reflectance ; Reproducibility of Results ; Sensitivity and Specificity ; Spectra ; Spectrometry, Fluorescence - methods ; Spectroscopy ; Young Adult</subject><ispartof>Journal of biomedical optics, 2009-01, Vol.14 (1), p.014028-014028</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-214abbbbcb74f00d3ab4b3df65f2ab3687dbc6cd310014b181d43831750cdc983</citedby><cites>FETCH-LOGICAL-c416t-214abbbbcb74f00d3ab4b3df65f2ab3687dbc6cd310014b181d43831750cdc983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19256716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Wei-Chiang</creatorcontrib><creatorcontrib>Sandberg, David I</creatorcontrib><creatorcontrib>Bhatia, Sanjiv</creatorcontrib><creatorcontrib>Johnson, Mahlon</creatorcontrib><creatorcontrib>Morrison, Glenn</creatorcontrib><creatorcontrib>Ragheb, John</creatorcontrib><title>Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions</title><title>Journal of biomedical optics</title><addtitle>J Biomed Opt</addtitle><description>The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy during surgical resection of epileptogenic cerebral cortex. Fluorescence spectra are measured at excitations of 337, 360, and 440 nm; diffuse reflectance spectra are measured between 400 and 900 nm from each specimen. Pathological analysis is performed to classify abnormalities in brain specimens, and its findings are correlated with spectral data. Statistically significant differences (p<0.01) are found for both raw and normalized diffuse reflectance and fluorescence spectra between 1. neoplastic brain and normal gray matter, 2. epileptogenic brain and normal gray matter, and 3. neoplastic brain and normal white matter. However, no distinct spectral features are identified that effectively separate epileptogenic brain from normal white matter. The outcomes of the study suggest that certain unique compositional and structural characteristics of pediatric neoplastic and epileptogenic brain can be detected using optical spectroscopy in vitro.</description><subject>Adolescent</subject><subject>Brain</subject><subject>Brain Chemistry</subject><subject>Brain Neoplasms - chemistry</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis, Computer-Assisted - methods</subject><subject>Diagnosis, Differential</subject><subject>Diffusion</subject><subject>Epilepsy - complications</subject><subject>Epilepsy - diagnosis</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>In vitro testing</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Patients</subject><subject>Reflectance</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectra</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>Spectroscopy</subject><subject>Young Adult</subject><issn>1083-3668</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhnNQbK0e_AOSk-Jha6bJZrNHKX5BoRc9L_mUyHYTk63Qf2-KC96cyzAvz7zMvAhdAVkCQHMPS0oEAcZO0ByIoBXlXMzQec6fhBDBW36GZtCuat4AnyO_jaPXssc5Wj2mkHWIB-xCwn6ovn1RsPHO2WSH0cvRhwEHh6M1ZUhe48GG2MtcPLAcDLbR9zaO4cMORVFJ-gH3Npe1fIFOneyzvZz6Ar0_Pb6tX6rN9vl1_bCpNAM-VitgUpXSqmGOEEOlYooax2u3kopy0RiluTYUSPlSgQDDqKDQ1EQb3Qq6QLe_vjGFr73NY7fzWdu-l-XWfe6EaFmh6ZG8-ZfkvBV1XbcFvPsFdQkoJ-u6mPxOpkMHpDum3kE3pV7Y68l0r3bW_JFT5PQHPJ2AjQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Lin, Wei-Chiang</creator><creator>Sandberg, David I</creator><creator>Bhatia, Sanjiv</creator><creator>Johnson, Mahlon</creator><creator>Morrison, Glenn</creator><creator>Ragheb, John</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20090101</creationdate><title>Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions</title><author>Lin, Wei-Chiang ; Sandberg, David I ; Bhatia, Sanjiv ; Johnson, Mahlon ; Morrison, Glenn ; Ragheb, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-214abbbbcb74f00d3ab4b3df65f2ab3687dbc6cd310014b181d43831750cdc983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Brain</topic><topic>Brain Chemistry</topic><topic>Brain Neoplasms - chemistry</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis, Computer-Assisted - methods</topic><topic>Diagnosis, Differential</topic><topic>Diffusion</topic><topic>Epilepsy - complications</topic><topic>Epilepsy - diagnosis</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>In vitro testing</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Patients</topic><topic>Reflectance</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectra</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>Spectroscopy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Wei-Chiang</creatorcontrib><creatorcontrib>Sandberg, David I</creatorcontrib><creatorcontrib>Bhatia, Sanjiv</creatorcontrib><creatorcontrib>Johnson, Mahlon</creatorcontrib><creatorcontrib>Morrison, Glenn</creatorcontrib><creatorcontrib>Ragheb, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Wei-Chiang</au><au>Sandberg, David I</au><au>Bhatia, Sanjiv</au><au>Johnson, Mahlon</au><au>Morrison, Glenn</au><au>Ragheb, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>14</volume><issue>1</issue><spage>014028</spage><epage>014028</epage><pages>014028-014028</pages><issn>1083-3668</issn><abstract>The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy during surgical resection of epileptogenic cerebral cortex. Fluorescence spectra are measured at excitations of 337, 360, and 440 nm; diffuse reflectance spectra are measured between 400 and 900 nm from each specimen. Pathological analysis is performed to classify abnormalities in brain specimens, and its findings are correlated with spectral data. Statistically significant differences (p<0.01) are found for both raw and normalized diffuse reflectance and fluorescence spectra between 1. neoplastic brain and normal gray matter, 2. epileptogenic brain and normal gray matter, and 3. neoplastic brain and normal white matter. However, no distinct spectral features are identified that effectively separate epileptogenic brain from normal white matter. The outcomes of the study suggest that certain unique compositional and structural characteristics of pediatric neoplastic and epileptogenic brain can be detected using optical spectroscopy in vitro.</abstract><cop>United States</cop><pmid>19256716</pmid><doi>10.1117/1.3080144</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of biomedical optics, 2009-01, Vol.14 (1), p.014028-014028 |
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| source | SPIE Digital Library (Journals); PubMed Central |
| subjects | Adolescent Brain Brain Chemistry Brain Neoplasms - chemistry Brain Neoplasms - complications Brain Neoplasms - diagnosis Child Child, Preschool Diagnosis, Computer-Assisted - methods Diagnosis, Differential Diffusion Epilepsy - complications Epilepsy - diagnosis Female Fluorescence Humans In vitro testing Infant Infant, Newborn Male Patients Reflectance Reproducibility of Results Sensitivity and Specificity Spectra Spectrometry, Fluorescence - methods Spectroscopy Young Adult |
| title | Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions |
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