Risk assessment of the application of a plasma jet in dermatology

Regardless of the fact that several highly efficient antiseptics are commercially available, the antiseptic treatment of chronic wounds remains a problem. In the past, electrical plasma discharges have been frequently used in biometrical science for disinfection and sterilization of material surface...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2009-09, Vol.14 (5), p.054025-054026
Main Authors: Lademann, Juergen, Richter, Heike, Alborova, Alena, Humme, Daniel, Patzelt, Alexa, Kramer, Axel, Weltmann, Klaus-Dieter, Hartmann, Bernd, Ottomann, Christian, Fluhr, Joachim W, Hinz, Peter, Hu¨bner, Georg, Lademann, Olaf
Format: Article
Language:English
Subjects:
Animals
Antiseptics
Biocompatibility
Biomedical materials
Culture
Dermatology - methods
Electrocoagulation - adverse effects
Electrocoagulation - methods
emission spectra
Erythema - diagnosis
Erythema - etiology
Erythema - prevention & control
In Vitro Techniques
In vivo testing
In vivo tests
infections
Risk Assessment
Risk Factors
skin
Skin Physiological Phenomena - radiation effects
Surgical implants
Swine
temperature
ultraviolet radiation
wound healing
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Summary:Regardless of the fact that several highly efficient antiseptics are commercially available, the antiseptic treatment of chronic wounds remains a problem. In the past, electrical plasma discharges have been frequently used in biometrical science for disinfection and sterilization of material surfaces. Plasma systems usually have a temperature of several hundred degrees. Recently, it was reported that "cold" plasma can be applied onto living tissue. In studies on cell culture, it could be demonstrated that this new plasma possesses excellent antiseptic properties. We perform a risk assessment concerning the application of a "cold" plasma jet on patients and volunteers. Two potential risk factors, UV radiation and temperature, are evaluated. We show that the UV radiation of the plasma in the used system is an order of magnitude lower than the minimal erythema dose, necessary to produce sunburn on the skin . Additionally, thermal damage of the tissue by the plasma can be excluded. The results of the risk assessment stimulate the application of the investigated plasma jet in the treatment of chronic wounds.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.3247156