A prospective study of intrafamilial transmission and antimicrobial susceptibility of Moraxella catarrhalis

ABSTRACT Moraxella catarrhalis has been recognized as a particularly threatening respiratory tract pathogen in humans. A prospective study was performed to investigate which strains of M. catarrhalis can be transmitted within families; the study also addressed features of antimicrobial susceptibilit...

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Bibliographic Details
Published in:Microbiology and immunology 2011-09, Vol.55 (9), p.599-604
Main Authors: Masaki, Hironori, Qin, Liang, Zhou, Zhaoyan, Onizuka, Tomoko, Watanabe, Kiwao, Hu, Bijie, Watanabe, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - pharmacology
antimicrobial susceptibility
beta-Lactamases - secretion
Child
Child, Preschool
Cluster Analysis
DNA, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field
Family Health
Female
Humans
intrafamilial transmission
Male
Microbial Sensitivity Tests
Molecular Typing
Moraxella (Branhamella) catarrhalis - classification
Moraxella (Branhamella) catarrhalis - drug effects
Moraxella (Branhamella) catarrhalis - enzymology
Moraxella (Branhamella) catarrhalis - isolation & purification
Moraxella catarrhalis
Moraxellaceae Infections - microbiology
Moraxellaceae Infections - transmission
Prospective Studies
pulsed-field gel electrophoresis
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Summary:ABSTRACT Moraxella catarrhalis has been recognized as a particularly threatening respiratory tract pathogen in humans. A prospective study was performed to investigate which strains of M. catarrhalis can be transmitted within families; the study also addressed features of antimicrobial susceptibility. Seventy‐five strains were isolated from six participants between July 2002 and February 2004, including 73 that were verified as beta‐lactamase‐producing strains. Antimicrobial susceptibility was tested for six types of antibiotics and no treatment issues were found. Pulsed‐field gel electrophoresis (PFGE) was performed on all strains and 25 independent PFGE patterns were detected. The dominant pattern L (defined in the present study) was found in 21 (28%) of strains that were continuously recovered from children from the same family over an 8‐month period. Strains with the patterns G, J, L, M, R, S, U, and W seemed to spread among the children, but there was no evidence of child‐parent transmission. In the present study, the characteristics of M. catarrhalis within families have been documented, and PFGE profiles found to reveal alternating colonization and intrafamilial transmission.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2011.00360.x