Successful Combined Heart-Bilateral Lung-Kidney Transplantation From a Same Donor to Treat Severe Hypertrophic Cardiomyopathy With Secondary Pulmonary Hypertension and Renal Failure: Case Report and Review of the Literature

Abstract This study describes the first reported case of a combined heart-lung-kidney transplantation. Our patient suffered from hypertrophic cardiomyopathy due to long-standing hypertension with Dana Point Classification Group 2 pulmonary hypertension from the underlying cardiac disease, along with...

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Bibliographic Details
Published in:Transplantation proceedings 2011-09, Vol.43 (7), p.2820-2826
Main Authors: Rana, R.K, Ghandehari, S, Falk, J.A, Simsir, S.A, Ghaly, A.S, Cheng, W, Cohen, J.L, Peng, A, Czer, L.S.C, Schwarz, E.R, Chaux, G.E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiomegaly - surgery
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart Transplantation
Humans
Hypertension, Pulmonary - surgery
Kidney Failure, Chronic - surgery
Kidney Transplantation
Lung Transplantation
Medical sciences
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Surgery of the urinary system
Tissue Donors
Tissue, organ and graft immunology
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Summary:Abstract This study describes the first reported case of a combined heart-lung-kidney transplantation. Our patient suffered from hypertrophic cardiomyopathy due to long-standing hypertension with Dana Point Classification Group 2 pulmonary hypertension from the underlying cardiac disease, along with renal failure necessitating renal replacement therapy. Twenty months after the transplant procedure, she has stable pulmonary and renal function, plus has resumed a normal daily life with improving exercise tolerance. We propose that a combined heart-lung-kidney transplantation may be an acceptable therapeutic option for carefully selected patients with advanced, concomitant cardiac, pulmonary, and kidney disease.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.07.007