Loading…
Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study
Purpose To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC. Methods We assessed 17,688 patie...
Saved in:
| Published in: | Annals of surgical oncology 2011-10, Vol.18 (10), p.2988-2996 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3 |
| container_end_page | 2996 |
| container_issue | 10 |
| container_start_page | 2988 |
| container_title | Annals of surgical oncology |
| container_volume | 18 |
| creator | Abdollah, Firas Sun, Maxine Thuret, Rodolphe Schmitges, Jan Shariat, Shahrokh F. Perrotte, Paul Montorsi, Francesco Karakiewicz, Pierre I. |
| description | Purpose
To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC.
Methods
We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Florida Inpatient Database. Chi-square and Student
t
-tests were used to compare the statistical significance of differences in proportions and means, respectively. Univariable and multivariable logistic regression analyses tested the relationship between surgery type (CNT vs. NT) and three end points: in-hospital mortality, complications, and transfusions.
Results
Overall, 6.0% of patients underwent CNT. The rates of in-hospital mortality, complications, and transfusions were 2.4, 26.5, and 24.3% in CNT patients versus 0.9, 18.9, and 11.1% in NT patients. At multivariable analyses, CNT patients demonstrated a 2.0-, 1.3-, and 2.4-fold higher risk of in-hospital mortality, complications, and transfusions (all
P
|
| doi_str_mv | 10.1245/s10434-011-1715-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_889452008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449661161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3</originalsourceid><addsrcrecordid>eNp1kU1v3CAQhlGVKt8_oJcI5ZKTE7AZA7ltVk0bKWmjfpwRi8eJI9tsAEfyvy-rTRspUi_ADM-8M_AS8omzc14KuIiciUoUjPOCSw5F-YHsc8gZUSu-k8-sVoUua9gjBzE-McZlxWCX7JVcaK2Y2ifTnQ_J9l2aqR0bmqNV12yiRZsw0OWcfMBmcql7QfoN148BXfLDTFsf6B0mG5NNnaM_cLQ9XWKfFxtcN_rBXtIFvffrqc-EH4srG7GhP9PUzEfkY2v7iMev-yH5ff351_Jrcfv9y81ycVu4SrJUVFIgs6gkaqaBQaUBrHJVLQBdCxpRcgsAjc4fITU6lHWr65UUVigHbXVIzra66-CfJ4zJDF10eUg7op-iUUoLKBlTmTx9Rz75KeQ3bSAlWV1WkCG-hVzwMQZszTp0gw2z4cxsHDFbR0x2xGwcMWWuOXkVnlYDNv8q_lqQgXILxHw1PmB46_x_1T-SF5ZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>888706235</pqid></control><display><type>article</type><title>Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study</title><source>Springer Link</source><creator>Abdollah, Firas ; Sun, Maxine ; Thuret, Rodolphe ; Schmitges, Jan ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I.</creator><creatorcontrib>Abdollah, Firas ; Sun, Maxine ; Thuret, Rodolphe ; Schmitges, Jan ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I.</creatorcontrib><description>Purpose
To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC.
Methods
We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Florida Inpatient Database. Chi-square and Student
t
-tests were used to compare the statistical significance of differences in proportions and means, respectively. Univariable and multivariable logistic regression analyses tested the relationship between surgery type (CNT vs. NT) and three end points: in-hospital mortality, complications, and transfusions.
Results
Overall, 6.0% of patients underwent CNT. The rates of in-hospital mortality, complications, and transfusions were 2.4, 26.5, and 24.3% in CNT patients versus 0.9, 18.9, and 11.1% in NT patients. At multivariable analyses, CNT patients demonstrated a 2.0-, 1.3-, and 2.4-fold higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001). Similarly, more advanced age, comorbidity, and the cumulative number of secondary surgical procedures were independent predictors of a higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001).
Conclusions
The rate of in-hospital mortality, complications, and transfusions is higher in patients treated with CNT relative to NT. Older age, higher comorbidity, and the necessity of secondary surgical procedures further increases the risk of all aforementioned end points. Physicians should consider these observations during the planning of a CNT, and patients should be informed accordingly.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-011-1715-2</identifier><identifier>PMID: 21499808</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - secondary ; Carcinoma, Renal Cell - surgery ; Female ; Florida - epidemiology ; Follow-Up Studies ; Hospital Mortality - trends ; Humans ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Morbidity ; Nephrectomy - mortality ; Oncology ; Postoperative Complications ; Prognosis ; Surgery ; Surgical Oncology ; Survival Rate ; Urologic Oncology</subject><ispartof>Annals of surgical oncology, 2011-10, Vol.18 (10), p.2988-2996</ispartof><rights>Society of Surgical Oncology 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3</citedby><cites>FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21499808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdollah, Firas</creatorcontrib><creatorcontrib>Sun, Maxine</creatorcontrib><creatorcontrib>Thuret, Rodolphe</creatorcontrib><creatorcontrib>Schmitges, Jan</creatorcontrib><creatorcontrib>Shariat, Shahrokh F.</creatorcontrib><creatorcontrib>Perrotte, Paul</creatorcontrib><creatorcontrib>Montorsi, Francesco</creatorcontrib><creatorcontrib>Karakiewicz, Pierre I.</creatorcontrib><title>Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Purpose
To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC.
Methods
We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Florida Inpatient Database. Chi-square and Student
t
-tests were used to compare the statistical significance of differences in proportions and means, respectively. Univariable and multivariable logistic regression analyses tested the relationship between surgery type (CNT vs. NT) and three end points: in-hospital mortality, complications, and transfusions.
Results
Overall, 6.0% of patients underwent CNT. The rates of in-hospital mortality, complications, and transfusions were 2.4, 26.5, and 24.3% in CNT patients versus 0.9, 18.9, and 11.1% in NT patients. At multivariable analyses, CNT patients demonstrated a 2.0-, 1.3-, and 2.4-fold higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001). Similarly, more advanced age, comorbidity, and the cumulative number of secondary surgical procedures were independent predictors of a higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001).
Conclusions
The rate of in-hospital mortality, complications, and transfusions is higher in patients treated with CNT relative to NT. Older age, higher comorbidity, and the necessity of secondary surgical procedures further increases the risk of all aforementioned end points. Physicians should consider these observations during the planning of a CNT, and patients should be informed accordingly.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - secondary</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Female</subject><subject>Florida - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Nephrectomy - mortality</subject><subject>Oncology</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Urologic Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v3CAQhlGVKt8_oJcI5ZKTE7AZA7ltVk0bKWmjfpwRi8eJI9tsAEfyvy-rTRspUi_ADM-8M_AS8omzc14KuIiciUoUjPOCSw5F-YHsc8gZUSu-k8-sVoUua9gjBzE-McZlxWCX7JVcaK2Y2ifTnQ_J9l2aqR0bmqNV12yiRZsw0OWcfMBmcql7QfoN148BXfLDTFsf6B0mG5NNnaM_cLQ9XWKfFxtcN_rBXtIFvffrqc-EH4srG7GhP9PUzEfkY2v7iMev-yH5ff351_Jrcfv9y81ycVu4SrJUVFIgs6gkaqaBQaUBrHJVLQBdCxpRcgsAjc4fITU6lHWr65UUVigHbXVIzra66-CfJ4zJDF10eUg7op-iUUoLKBlTmTx9Rz75KeQ3bSAlWV1WkCG-hVzwMQZszTp0gw2z4cxsHDFbR0x2xGwcMWWuOXkVnlYDNv8q_lqQgXILxHw1PmB46_x_1T-SF5ZI</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Abdollah, Firas</creator><creator>Sun, Maxine</creator><creator>Thuret, Rodolphe</creator><creator>Schmitges, Jan</creator><creator>Shariat, Shahrokh F.</creator><creator>Perrotte, Paul</creator><creator>Montorsi, Francesco</creator><creator>Karakiewicz, Pierre I.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study</title><author>Abdollah, Firas ; Sun, Maxine ; Thuret, Rodolphe ; Schmitges, Jan ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - secondary</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Female</topic><topic>Florida - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Nephrectomy - mortality</topic><topic>Oncology</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Urologic Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdollah, Firas</creatorcontrib><creatorcontrib>Sun, Maxine</creatorcontrib><creatorcontrib>Thuret, Rodolphe</creatorcontrib><creatorcontrib>Schmitges, Jan</creatorcontrib><creatorcontrib>Shariat, Shahrokh F.</creatorcontrib><creatorcontrib>Perrotte, Paul</creatorcontrib><creatorcontrib>Montorsi, Francesco</creatorcontrib><creatorcontrib>Karakiewicz, Pierre I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdollah, Firas</au><au>Sun, Maxine</au><au>Thuret, Rodolphe</au><au>Schmitges, Jan</au><au>Shariat, Shahrokh F.</au><au>Perrotte, Paul</au><au>Montorsi, Francesco</au><au>Karakiewicz, Pierre I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>18</volume><issue>10</issue><spage>2988</spage><epage>2996</epage><pages>2988-2996</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Purpose
To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC.
Methods
We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Florida Inpatient Database. Chi-square and Student
t
-tests were used to compare the statistical significance of differences in proportions and means, respectively. Univariable and multivariable logistic regression analyses tested the relationship between surgery type (CNT vs. NT) and three end points: in-hospital mortality, complications, and transfusions.
Results
Overall, 6.0% of patients underwent CNT. The rates of in-hospital mortality, complications, and transfusions were 2.4, 26.5, and 24.3% in CNT patients versus 0.9, 18.9, and 11.1% in NT patients. At multivariable analyses, CNT patients demonstrated a 2.0-, 1.3-, and 2.4-fold higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001). Similarly, more advanced age, comorbidity, and the cumulative number of secondary surgical procedures were independent predictors of a higher risk of in-hospital mortality, complications, and transfusions (all
P
< 0.001).
Conclusions
The rate of in-hospital mortality, complications, and transfusions is higher in patients treated with CNT relative to NT. Older age, higher comorbidity, and the necessity of secondary surgical procedures further increases the risk of all aforementioned end points. Physicians should consider these observations during the planning of a CNT, and patients should be informed accordingly.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21499808</pmid><doi>10.1245/s10434-011-1715-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2011-10, Vol.18 (10), p.2988-2996 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_889452008 |
| source | Springer Link |
| subjects | Aged Aged, 80 and over Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - surgery Female Florida - epidemiology Follow-Up Studies Hospital Mortality - trends Humans Kidney Neoplasms - epidemiology Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Morbidity Nephrectomy - mortality Oncology Postoperative Complications Prognosis Surgery Surgical Oncology Survival Rate Urologic Oncology |
| title | Mortality and Morbidity After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: A Population-Based Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T17%3A36%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mortality%20and%20Morbidity%20After%20Cytoreductive%20Nephrectomy%20for%20Metastatic%20Renal%20Cell%20Carcinoma:%20A%20Population-Based%20Study&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Abdollah,%20Firas&rft.date=2011-10-01&rft.volume=18&rft.issue=10&rft.spage=2988&rft.epage=2996&rft.pages=2988-2996&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-011-1715-2&rft_dat=%3Cproquest_cross%3E2449661161%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c370t-374e0ae87e9095053955a8c3645ecf59ee71a555d910479ece76f96b74a48c5f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=888706235&rft_id=info:pmid/21499808&rfr_iscdi=true |