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Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae
Objective. To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score. Methods. This randomized study included 101 primigravidae women wit...
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| Published in: | The journal of maternal-fetal & neonatal medicine 2011-09, Vol.24 (9), p.1084-1087 |
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| container_end_page | 1087 |
| container_issue | 9 |
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| container_title | The journal of maternal-fetal & neonatal medicine |
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| creator | Balci, Osman Mahmoud, Alaa S. Acar, Ali Colakoglu, Mehmet C. |
| description | Objective. To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score.
Methods. This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of |
| doi_str_mv | 10.3109/14767058.2010.531798 |
| format | article |
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Methods. This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of <6. Group 1 (50 patients) received a 50-μg dose of intravaginal misoprostol, with an oxytocin infusion started 3 h later. Group 2 (51 patients) received only an oxytocin infusion for labor induction. The time from induction to delivery, the route of delivery and complications were analyzed.
Results. The mean time from induction to delivery was 10.4 ± 2.1 h in Group 1 and 13.7 ± 3.4 in Group 2 (p < 0.001). The rates of vaginal delivery, Apgar scores at 1st and 5th min, placental abruption, and postpartum hemorrhage were similar between the two groups.
Conclusion. Intravaginal application of 50-μg misoprostol before starting oxytocin infusion is a more effective method of labor induction than oxytocin infusion alone in term primigravidae pregnant women with low-Bishop scores.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.3109/14767058.2010.531798</identifier><identifier>PMID: 21087166</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Administration, Intravaginal ; Adult ; Drug Combinations ; Female ; Follow-Up Studies ; Gravidity - physiology ; Humans ; Labor induction ; Labor, Induced - adverse effects ; Labor, Induced - methods ; misoprostol ; Misoprostol - administration & dosage ; Misoprostol - adverse effects ; Oxytocics - administration & dosage ; oxytocin ; Oxytocin - administration & dosage ; Oxytocin - adverse effects ; Postpartum Hemorrhage - chemically induced ; Postpartum Hemorrhage - epidemiology ; Pregnancy ; Term Birth - drug effects ; Term Birth - physiology ; Young Adult</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2011-09, Vol.24 (9), p.1084-1087</ispartof><rights>2011 Informa UK, Ltd. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c9b44eff3acadde2b5d3f2413695ce97ccc81cd8dc3a5bb6a84f8d5698b279593</citedby><cites>FETCH-LOGICAL-c417t-c9b44eff3acadde2b5d3f2413695ce97ccc81cd8dc3a5bb6a84f8d5698b279593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21087166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balci, Osman</creatorcontrib><creatorcontrib>Mahmoud, Alaa S.</creatorcontrib><creatorcontrib>Acar, Ali</creatorcontrib><creatorcontrib>Colakoglu, Mehmet C.</creatorcontrib><title>Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Objective. To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score.
Methods. This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of <6. Group 1 (50 patients) received a 50-μg dose of intravaginal misoprostol, with an oxytocin infusion started 3 h later. Group 2 (51 patients) received only an oxytocin infusion for labor induction. The time from induction to delivery, the route of delivery and complications were analyzed.
Results. The mean time from induction to delivery was 10.4 ± 2.1 h in Group 1 and 13.7 ± 3.4 in Group 2 (p < 0.001). The rates of vaginal delivery, Apgar scores at 1st and 5th min, placental abruption, and postpartum hemorrhage were similar between the two groups.
Conclusion. Intravaginal application of 50-μg misoprostol before starting oxytocin infusion is a more effective method of labor induction than oxytocin infusion alone in term primigravidae pregnant women with low-Bishop scores.</description><subject>Administration, Intravaginal</subject><subject>Adult</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gravidity - physiology</subject><subject>Humans</subject><subject>Labor induction</subject><subject>Labor, Induced - adverse effects</subject><subject>Labor, Induced - methods</subject><subject>misoprostol</subject><subject>Misoprostol - administration & dosage</subject><subject>Misoprostol - adverse effects</subject><subject>Oxytocics - administration & dosage</subject><subject>oxytocin</subject><subject>Oxytocin - administration & dosage</subject><subject>Oxytocin - adverse effects</subject><subject>Postpartum Hemorrhage - chemically induced</subject><subject>Postpartum Hemorrhage - epidemiology</subject><subject>Pregnancy</subject><subject>Term Birth - drug effects</subject><subject>Term Birth - physiology</subject><subject>Young Adult</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kcFvFCEUxomxsbX6HxjDzdNWGGAGLhqzadWkiZd6Jm-A6dIwwwrM1v3vZTJbo5ee4L383vc-PhB6R8kVo0R9pLxrOyLkVUNqSzDaKfkCXSztDVeCvzzdF-Ycvc75gZCGciJeofOGEtnRtr1AeRvHPSSf44TjgP1kZ1P8WgToY8KPvuzwAe79BAGPFdynmEsMeB_mjOPvY4nGT_jgUv63hhAnV_VwcWnE--RHf5_g4C24N-hsgJDd29N5iX7eXN9tv21uf3z9vv1yuzGcdmVjVM-5GwYGBqx1TS8sGxpOWauEcaozxkhqrLSGgej7FiQfpBWtkn3TKaHYJfqw6lbHv2aXi672jQsBJhfnrKUihFHOFpKvpKlvy8kNejEM6agp0Uva-iltvaSt17Tr2PvTgrkfnf079BRvBT6vgJ-GmEZ4jClYXeAYYhoSTMbnRf7ZFZ_-U9g5CGVnIDn9EOdU_yQ_7_EPZwql7w</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Balci, Osman</creator><creator>Mahmoud, Alaa S.</creator><creator>Acar, Ali</creator><creator>Colakoglu, Mehmet C.</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae</title><author>Balci, Osman ; Mahmoud, Alaa S. ; Acar, Ali ; Colakoglu, Mehmet C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c9b44eff3acadde2b5d3f2413695ce97ccc81cd8dc3a5bb6a84f8d5698b279593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Intravaginal</topic><topic>Adult</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gravidity - physiology</topic><topic>Humans</topic><topic>Labor induction</topic><topic>Labor, Induced - adverse effects</topic><topic>Labor, Induced - methods</topic><topic>misoprostol</topic><topic>Misoprostol - administration & dosage</topic><topic>Misoprostol - adverse effects</topic><topic>Oxytocics - administration & dosage</topic><topic>oxytocin</topic><topic>Oxytocin - administration & dosage</topic><topic>Oxytocin - adverse effects</topic><topic>Postpartum Hemorrhage - chemically induced</topic><topic>Postpartum Hemorrhage - epidemiology</topic><topic>Pregnancy</topic><topic>Term Birth - drug effects</topic><topic>Term Birth - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balci, Osman</creatorcontrib><creatorcontrib>Mahmoud, Alaa S.</creatorcontrib><creatorcontrib>Acar, Ali</creatorcontrib><creatorcontrib>Colakoglu, Mehmet C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balci, Osman</au><au>Mahmoud, Alaa S.</au><au>Acar, Ali</au><au>Colakoglu, Mehmet C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2011-09</date><risdate>2011</risdate><volume>24</volume><issue>9</issue><spage>1084</spage><epage>1087</epage><pages>1084-1087</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Objective. To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score.
Methods. This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of <6. Group 1 (50 patients) received a 50-μg dose of intravaginal misoprostol, with an oxytocin infusion started 3 h later. Group 2 (51 patients) received only an oxytocin infusion for labor induction. The time from induction to delivery, the route of delivery and complications were analyzed.
Results. The mean time from induction to delivery was 10.4 ± 2.1 h in Group 1 and 13.7 ± 3.4 in Group 2 (p < 0.001). The rates of vaginal delivery, Apgar scores at 1st and 5th min, placental abruption, and postpartum hemorrhage were similar between the two groups.
Conclusion. Intravaginal application of 50-μg misoprostol before starting oxytocin infusion is a more effective method of labor induction than oxytocin infusion alone in term primigravidae pregnant women with low-Bishop scores.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>21087166</pmid><doi>10.3109/14767058.2010.531798</doi><tpages>4</tpages></addata></record> |
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| subjects | Administration, Intravaginal Adult Drug Combinations Female Follow-Up Studies Gravidity - physiology Humans Labor induction Labor, Induced - adverse effects Labor, Induced - methods misoprostol Misoprostol - administration & dosage Misoprostol - adverse effects Oxytocics - administration & dosage oxytocin Oxytocin - administration & dosage Oxytocin - adverse effects Postpartum Hemorrhage - chemically induced Postpartum Hemorrhage - epidemiology Pregnancy Term Birth - drug effects Term Birth - physiology Young Adult |
| title | Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae |
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