A slightly elevated level of N-terminal pro-brain natriuretic peptide can predict coronary artery disease in a population with normal left ventricular function

• Published in: Heart and vessels 2011-09, Vol.26 (5), p.473-479
• Main Authors: Ikeda, Nobutaka, Nakamura, Masato, Yazaki, Yoshiyuki, Ono, Tsuyoshi, Yamamoto, Masaya, Ito, Shingo, Yokouchi, Itaru, Yajima, Suguru, Iijima, Raisuke, Hara, Hidehiko, Takagi, Takuro, Hara, Hisao, Asahara, Toshiyuki, Sakai, Hideyuki, Sugi, Kaoru
• Format: Article
• Language: English
• Subjects: Aged; Anemia; Angiography; Arteriography; Biomarkers; Biomarkers - blood; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiology; Cardiovascular disease; Case-Control Studies; Chi-Square Distribution; Coronary Angiography; coronary artery; Coronary Stenosis - blood; Coronary Stenosis - diagnosis; Coronary Stenosis - physiopathology; Data processing; Echocardiography; Female; Fibrillation; Heart; Heart diseases; Humans; Ischemia; Japan; Kidney diseases; Lipoproteins; Lipoproteins (high density); Lipoproteins (low density); Lung diseases; Male; Medicine; Medicine & Public Health; Middle Aged; Myocardial infarction; Natriuretic Peptide, Brain - blood; Odds Ratio; Original Article; Peptide Fragments - blood; Peptides; Predictive Value of Tests; Prospective Studies; Renal function; ROC Curve; Sensitivity and Specificity; Stenosis; Up-Regulation; Vascular Surgery; Ventricle; Ventricular Function, Left
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-010-0080-6

The prognostic and diagnostic values of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in ischemic heart disease have already been investigated in many previous studies. Although NT-pro-BNP is affected by many factors, these previous studies did not strictly exclude them. This study included 110 patients who received coronary arteriography between November 2007 and September 2009. Excluded from the study were those patients who had clinical symptoms of heart failure, asynergy by echocardiography or left ventriculography (LVG), atrial fibrillation, prior myocardial infarction, valvular disease, lung disease, anemia or renal dysfunction. We compared the laboratory data, LVG and early transmitral-to-early diastolic annular velocity ratio ( E / E a ) in echocardiography between the group with coronary stenosis and the group without it. NT-pro-BNP and the low-density lipoprotein/high-density lipoprotein ratio (LDL/HDL) independently associated with the presence of coronary artery stenosis (odds ratio of NT-pro-BNP, each 50 pg/ml 2.367, 95% confidence interval 1.302–4.303, p  = 0.005). The area under the curve of the receiver-operating characteristic (ROC) curve of NT-pro-BNP, used to predict coronary artery stenosis, was 0.801 (0.719–0.883, p