Antifungal activity of Ocimum sanctum Linn.(Lamiaceae) on clinically isolated dermatophytic fungi

• Published in: Asian Pacific journal of tropical medicine 2011-08, Vol.4 (8), p.654-657
• Main Authors: Balakumar, S, Rajan, S, Thirunalasundari, T, Jeeva, S
• Format: Article
• Language: English
• Subjects: activity; Antifungal; Antifungal activity; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; concentration; Dermatophytosis; Epidermophyton; Epidermophyton - drug effects; Epidermophyton - physiology; Epidermophyton floccosum; floccosum; fungicidal; Humans; inhibitory; Miconazole - pharmacology; Microbial Sensitivity Tests; Microsporum; Microsporum sp; Minimum; Minimum fungicidal concentration; Minimum inhibitory concentration; Ocimum; Ocimum - chemistry; Ocimum sanctum; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves - chemistry; sanctum; Solvents; Tinea - drug therapy; Tinea - microbiology; Trichophyton; Trichophyton sp; Water
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(11)60166-1

<正>Objective:To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. Methods:Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.Results:Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200μg/mL.MIC and MFC were high with water fraction(200μg/mL) against dermatophytic fungi used.Conclusions:Ocimum sanctum has antifungal activity,and the leaf extracts may be a useful source for dermatophytic infections.