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Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer
Background Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure...
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| Published in: | Journal of gastroenterology 2011-09, Vol.46 (9), p.1064-1070 |
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| container_title | Journal of gastroenterology |
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| creator | Kobayashi, Masaaki Takeuchi, Manabu Ajioka, Yoichi Hashimoto, Satoru Sato, Akito Narisawa, Rintaro Aoyagi, Yutaka |
| description | Background
Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure in a fine network pattern (FNP). However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP.
Methods
We evaluated 120 intramucosal, well- or predominantly well-differentiated tubular adenocarcinomas. In each lesion, one area that showed the predominant pattern of microsurface structures and microvessels was selected and marked by electrocoagulation for a strict comparative study by NBI-ME and pathological investigation. NBI-ME findings were classified into three patterns: ILL, FNP, and intermediate. Mucin phenotypes were judged as gastric, intestinal, or gastrointestinal type by immunohistochemistry.
Results
The mucin phenotype was gastric or gastrointestinal type in 24 (92.3%) of 26 ILL lesions. Intestinal phenotype was observed in 22 (84.6%) of 26 FNP lesions. The gastrointestinal phenotype was observed in 50 (73.5%) of 68 intermediate pattern lesions. The mucin phenotype and NBI-ME results were significantly correlated (
P
|
| doi_str_mv | 10.1007/s00535-011-0418-6 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_890036280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714586106</galeid><sourcerecordid>A714586106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-7d4e4c0ee10bbc1f3bd900792f25ac126b60773662f3b714591f1a27e2c72e643</originalsourceid><addsrcrecordid>eNp1kU-P1iAQxonRuK-rH8CLafTgqesMpbQ9bjb-S9Z40TOhdOiy6QsV2mzeby-1q0aj4cAw85uHgYex5wgXCNC8SQB1VZeAWILAtpQP2AFFztQd5w_ZATohSsRGnLEnKd0CYAV1-5idcZSywRoPbP60GueL-YZ8WE4zFdoPhdcxhruy32J31KPzY3Hnlpsix97Z03YmP4RkwnwqbIjF4KylSH5xeqGh_KF0XE1IeipGnZboTGG0NxSfskdWT4me3e_n7Ou7t1-uPpTXn99_vLq8Lo3oYCmbQZAwQITQ9wZt1Q9dfnLHLa-1QS57CU1TSclzqUFRd2hR84a4aThJUZ2z17vuHMO3ldKiji4ZmibtKaxJtVmukryFTL78i7wNa_R5ONW2HbZ1DV2GXu3QqCdSztuwRG02SXW5Xd9KBJmpi39QeQ10dCZ4si7n_2jAvcHEkFIkq-aYfzyeFILaPFa7xyp7rDaP1dbz4n7etT_S8Kvjp6kZ4DuQcsmPFH8_6P-q3wH5x7Cy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>889185509</pqid></control><display><type>article</type><title>Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer</title><source>Springer Nature</source><creator>Kobayashi, Masaaki ; Takeuchi, Manabu ; Ajioka, Yoichi ; Hashimoto, Satoru ; Sato, Akito ; Narisawa, Rintaro ; Aoyagi, Yutaka</creator><creatorcontrib>Kobayashi, Masaaki ; Takeuchi, Manabu ; Ajioka, Yoichi ; Hashimoto, Satoru ; Sato, Akito ; Narisawa, Rintaro ; Aoyagi, Yutaka</creatorcontrib><description>Background
Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure in a fine network pattern (FNP). However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP.
Methods
We evaluated 120 intramucosal, well- or predominantly well-differentiated tubular adenocarcinomas. In each lesion, one area that showed the predominant pattern of microsurface structures and microvessels was selected and marked by electrocoagulation for a strict comparative study by NBI-ME and pathological investigation. NBI-ME findings were classified into three patterns: ILL, FNP, and intermediate. Mucin phenotypes were judged as gastric, intestinal, or gastrointestinal type by immunohistochemistry.
Results
The mucin phenotype was gastric or gastrointestinal type in 24 (92.3%) of 26 ILL lesions. Intestinal phenotype was observed in 22 (84.6%) of 26 FNP lesions. The gastrointestinal phenotype was observed in 50 (73.5%) of 68 intermediate pattern lesions. The mucin phenotype and NBI-ME results were significantly correlated (
P
< 0.001).
Conclusions
The mucin phenotype of differentiated early gastric cancer might be involved in morphogenetic differences between the papillary and pit structures visualized by NBI-ME.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-011-0418-6</identifier><identifier>PMID: 21667151</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Adenocarcinoma - blood supply ; Adenocarcinoma - classification ; Adenocarcinoma - pathology ; Aged ; Aged, 80 and over ; Cancer ; Colorectal Surgery ; Endoscopy ; Endoscopy, Gastrointestinal - methods ; Female ; Gastric Mucosa - pathology ; Gastroenterology ; Genetic aspects ; Hepatology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Microvessels ; Middle Aged ; Mucins - metabolism ; Oncology, Experimental ; Original Article—Alimentary Tract ; Phenotype ; Stomach cancer ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - classification ; Stomach Neoplasms - pathology ; Surgical Oncology</subject><ispartof>Journal of gastroenterology, 2011-09, Vol.46 (9), p.1064-1070</ispartof><rights>Springer 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-7d4e4c0ee10bbc1f3bd900792f25ac126b60773662f3b714591f1a27e2c72e643</citedby><cites>FETCH-LOGICAL-c490t-7d4e4c0ee10bbc1f3bd900792f25ac126b60773662f3b714591f1a27e2c72e643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21667151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Masaaki</creatorcontrib><creatorcontrib>Takeuchi, Manabu</creatorcontrib><creatorcontrib>Ajioka, Yoichi</creatorcontrib><creatorcontrib>Hashimoto, Satoru</creatorcontrib><creatorcontrib>Sato, Akito</creatorcontrib><creatorcontrib>Narisawa, Rintaro</creatorcontrib><creatorcontrib>Aoyagi, Yutaka</creatorcontrib><title>Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure in a fine network pattern (FNP). However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP.
Methods
We evaluated 120 intramucosal, well- or predominantly well-differentiated tubular adenocarcinomas. In each lesion, one area that showed the predominant pattern of microsurface structures and microvessels was selected and marked by electrocoagulation for a strict comparative study by NBI-ME and pathological investigation. NBI-ME findings were classified into three patterns: ILL, FNP, and intermediate. Mucin phenotypes were judged as gastric, intestinal, or gastrointestinal type by immunohistochemistry.
Results
The mucin phenotype was gastric or gastrointestinal type in 24 (92.3%) of 26 ILL lesions. Intestinal phenotype was observed in 22 (84.6%) of 26 FNP lesions. The gastrointestinal phenotype was observed in 50 (73.5%) of 68 intermediate pattern lesions. The mucin phenotype and NBI-ME results were significantly correlated (
P
< 0.001).
Conclusions
The mucin phenotype of differentiated early gastric cancer might be involved in morphogenetic differences between the papillary and pit structures visualized by NBI-ME.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - classification</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Colorectal Surgery</subject><subject>Endoscopy</subject><subject>Endoscopy, Gastrointestinal - methods</subject><subject>Female</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroenterology</subject><subject>Genetic aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvessels</subject><subject>Middle Aged</subject><subject>Mucins - metabolism</subject><subject>Oncology, Experimental</subject><subject>Original Article—Alimentary Tract</subject><subject>Phenotype</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - blood supply</subject><subject>Stomach Neoplasms - classification</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgical Oncology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kU-P1iAQxonRuK-rH8CLafTgqesMpbQ9bjb-S9Z40TOhdOiy6QsV2mzeby-1q0aj4cAw85uHgYex5wgXCNC8SQB1VZeAWILAtpQP2AFFztQd5w_ZATohSsRGnLEnKd0CYAV1-5idcZSywRoPbP60GueL-YZ8WE4zFdoPhdcxhruy32J31KPzY3Hnlpsix97Z03YmP4RkwnwqbIjF4KylSH5xeqGh_KF0XE1IeipGnZboTGG0NxSfskdWT4me3e_n7Ou7t1-uPpTXn99_vLq8Lo3oYCmbQZAwQITQ9wZt1Q9dfnLHLa-1QS57CU1TSclzqUFRd2hR84a4aThJUZ2z17vuHMO3ldKiji4ZmibtKaxJtVmukryFTL78i7wNa_R5ONW2HbZ1DV2GXu3QqCdSztuwRG02SXW5Xd9KBJmpi39QeQ10dCZ4si7n_2jAvcHEkFIkq-aYfzyeFILaPFa7xyp7rDaP1dbz4n7etT_S8Kvjp6kZ4DuQcsmPFH8_6P-q3wH5x7Cy</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Kobayashi, Masaaki</creator><creator>Takeuchi, Manabu</creator><creator>Ajioka, Yoichi</creator><creator>Hashimoto, Satoru</creator><creator>Sato, Akito</creator><creator>Narisawa, Rintaro</creator><creator>Aoyagi, Yutaka</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer</title><author>Kobayashi, Masaaki ; Takeuchi, Manabu ; Ajioka, Yoichi ; Hashimoto, Satoru ; Sato, Akito ; Narisawa, Rintaro ; Aoyagi, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-7d4e4c0ee10bbc1f3bd900792f25ac126b60773662f3b714591f1a27e2c72e643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - classification</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Colorectal Surgery</topic><topic>Endoscopy</topic><topic>Endoscopy, Gastrointestinal - methods</topic><topic>Female</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastroenterology</topic><topic>Genetic aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvessels</topic><topic>Middle Aged</topic><topic>Mucins - metabolism</topic><topic>Oncology, Experimental</topic><topic>Original Article—Alimentary Tract</topic><topic>Phenotype</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - blood supply</topic><topic>Stomach Neoplasms - classification</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Masaaki</creatorcontrib><creatorcontrib>Takeuchi, Manabu</creatorcontrib><creatorcontrib>Ajioka, Yoichi</creatorcontrib><creatorcontrib>Hashimoto, Satoru</creatorcontrib><creatorcontrib>Sato, Akito</creatorcontrib><creatorcontrib>Narisawa, Rintaro</creatorcontrib><creatorcontrib>Aoyagi, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Masaaki</au><au>Takeuchi, Manabu</au><au>Ajioka, Yoichi</au><au>Hashimoto, Satoru</au><au>Sato, Akito</au><au>Narisawa, Rintaro</au><au>Aoyagi, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>46</volume><issue>9</issue><spage>1064</spage><epage>1070</epage><pages>1064-1070</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure in a fine network pattern (FNP). However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP.
Methods
We evaluated 120 intramucosal, well- or predominantly well-differentiated tubular adenocarcinomas. In each lesion, one area that showed the predominant pattern of microsurface structures and microvessels was selected and marked by electrocoagulation for a strict comparative study by NBI-ME and pathological investigation. NBI-ME findings were classified into three patterns: ILL, FNP, and intermediate. Mucin phenotypes were judged as gastric, intestinal, or gastrointestinal type by immunohistochemistry.
Results
The mucin phenotype was gastric or gastrointestinal type in 24 (92.3%) of 26 ILL lesions. Intestinal phenotype was observed in 22 (84.6%) of 26 FNP lesions. The gastrointestinal phenotype was observed in 50 (73.5%) of 68 intermediate pattern lesions. The mucin phenotype and NBI-ME results were significantly correlated (
P
< 0.001).
Conclusions
The mucin phenotype of differentiated early gastric cancer might be involved in morphogenetic differences between the papillary and pit structures visualized by NBI-ME.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21667151</pmid><doi>10.1007/s00535-011-0418-6</doi><tpages>7</tpages></addata></record> |
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| subjects | Abdominal Surgery Adenocarcinoma - blood supply Adenocarcinoma - classification Adenocarcinoma - pathology Aged Aged, 80 and over Cancer Colorectal Surgery Endoscopy Endoscopy, Gastrointestinal - methods Female Gastric Mucosa - pathology Gastroenterology Genetic aspects Hepatology Humans Male Medicine Medicine & Public Health Microvessels Middle Aged Mucins - metabolism Oncology, Experimental Original Article—Alimentary Tract Phenotype Stomach cancer Stomach Neoplasms - blood supply Stomach Neoplasms - classification Stomach Neoplasms - pathology Surgical Oncology |
| title | Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer |
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