Relation between (99m)Tc-tetrofosmin thyroid scintigraphy and mitogen-activated protein kinase in papillary thyroid cancer patients

The aim of this study was to investigate the relation between (99m)Tc-tetrofosmin uptake and extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) expression in papillary thyroid cancer patients. Our study population consisted of 14 patients. The histopathological finding...

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Bibliographic Details
Published in:Japanese journal of radiology 2011-10, Vol.29 (8), p.533-539
Main Authors: Baba, Kenkichi, Ishibashi, Masatoshi, Kaida, Hayato, Fujii, Teruhiko, Hiromatsu, Yuji, Kawahara, Akihiko, Kage, Masayoshi, Hayabuchi, Naofumi
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Carcinoma
Carcinoma, Papillary
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Mitogen-Activated Protein Kinases - metabolism
Organophosphorus Compounds
Organotechnetium Compounds
Radionuclide Imaging
Radiopharmaceuticals
Statistics, Nonparametric
Thyroid Cancer, Papillary
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - enzymology
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
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Summary:The aim of this study was to investigate the relation between (99m)Tc-tetrofosmin uptake and extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) expression in papillary thyroid cancer patients. Our study population consisted of 14 patients. The histopathological findings for all patients were confirmed by surgery. Patients were administ 740 MBq of (99m)Tc-tetrofosmin. The tumor/background (T/B) ratios in regions of interest (ROIs) were measured at 10 min, 1 h, and 3 h to determine the uptake by papillary cancer. Immunohistopathological staining was performed, and the expression of phospho-ERK MAPK in papillary cancer was investigated. The relation between the expression of phospho-ERK MAPK and the T/B ratio was examined using the Mann-Whitney U-test. (99m)Tc-tetrofosmin uptake was positive in all patients. There was a statistically significant relation between the T/B ratio (at 3 h) and the expression of phospho-ERK MAPK but not with the T/B ratio at 10 min or 1 h: T/B ratio at 10 min (P = 0.32), at 1 h (P = 0.62), and at 3 h (P = 0.0072). Our results suggest that the relation between (99m)Tc-tetrofosmin uptake (3 h T/B ratio) may lead us to assume cell proliferation of papillary cancer.
ISSN:1867-108X
DOI:10.1007/s11604-011-0592-8