Basic and Therapeutic Aspects of Angiogenesis

Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but lim...

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Bibliographic Details
Published in:Cell 2011-09, Vol.146 (6), p.873-887
Main Authors: Potente, Michael, Gerhardt, Holger, Carmeliet, Peter
Format: Article
Language:English
Subjects:
angiogenesis
Angiogenesis Inhibitors - pharmacology
Angiogenesis Inhibitors - therapeutic use
Animals
blood vessels
Blood Vessels - cytology
Blood Vessels - embryology
disease course
diseases
endothelial cells
Endothelial Cells - drug effects
Endothelial Cells - physiology
growth
Humans
Inflammation - drug therapy
medicine
Neovascularization, Pathologic - drug therapy
Neovascularization, Physiologic
networks
tissues
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Summary:Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2011.08.039