A historical review of XDR tuberculosis in the Western Cape province of South Africa

There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 19...

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Bibliographic Details
Published in:South African medical journal 2011-09, Vol.101 (9), p.636-638
Main Authors: Symons, Gregory, Shean, Karen, Pietersen, Elize, Van Zyl Smit, Richard, Pool, Lititia, Davids, Malika, Willcox, Paul, Dheda, Keertan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Diagnosis
Drug resistance in microorganisms
Drug Resistance, Bacterial
Drug therapy
Extensively Drug-Resistant Tuberculosis - drug therapy
Extensively Drug-Resistant Tuberculosis - epidemiology
Extensively Drug-Resistant Tuberculosis - mortality
Female
Humans
Male
Middle Aged
Patient outcomes
Prevention
Public health
South Africa - epidemiology
Tuberculosis
Young Adult
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Summary:There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.
ISSN:0256-9574