Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys

A number of commonly recognized public health issues are associated with EV71 infection, including the induction of severe cases of hand-foot-and-mouth disease (HFMD). Because of such issues, research and development of EV71 vaccine candidates is of growing importance. In the present study, an exper...

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Bibliographic Details
Published in:Vaccine 2011-08, Vol.29 (37), p.6269-6275
Main Authors: Dong, Chenghong, Liu, Longding, Zhao, Hongling, Wang, Jingjing, Liao, Yun, Zhang, Xuemei, Na, Ruixiong, Liang, Yan, Wang, Lichun, Li, Qihan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal models
Animals
Antibodies, Neutralizing - blood
Applied microbiology
Biological and medical sciences
Enterovirus
Enterovirus A, Human - immunology
Enterovirus Infections - immunology
Enterovirus Infections - prevention & control
Enterovirus Infections - virology
Enterovirus type 71
Female
Fundamental and applied biological sciences. Psychology
hand, foot and mouth disease
immune response
Immunity, Cellular
Immunity, Humoral
Immunogenicity
Immunoprotection
Inactivated vaccine
Infections
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Macaca mulatta
Medical research
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Public health
R&D
Research & development
research and development
RNA, Viral - analysis
RNA, Viral - blood
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Viral infections
Viral Load
Viral Vaccines - immunology
Virology
Viruses
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Summary:A number of commonly recognized public health issues are associated with EV71 infection, including the induction of severe cases of hand-foot-and-mouth disease (HFMD). Because of such issues, research and development of EV71 vaccine candidates is of growing importance. In the present study, an experimental EV71 inactivated vaccine was prepared, and its corresponding immunogenicity was analyzed. The immune responses and immunoprotective effect induced by the vaccine in mice and rhesus monkeys are described, and the two animal models are compared to evaluate the potential of assessing the inactivated vaccine's immunogenicity in these two species. In addition to assessing the vaccine's efficacy in mice, our data further elucidate the significance and value of assessing the immunogenicity and immunoprotection of vaccine candidates in rhesus monkeys by relying on a range of analyses, including pathological, etiological and lethal challenge analyses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.06.044