Calpains and Delayed Calcium Deregulation in Excitotoxicity

Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases cal...

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Bibliographic Details
Published in:Neurochemical research 2010-12, Vol.35 (12), p.1966-1969
Main Authors: Araújo, Inês M., Carreira, Bruno P., Carvalho, Caetana M., Carvalho, Arsélio P.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Calcium - physiology
Calpain - metabolism
Calpain - physiology
Cell Biology
Enzyme Activation
Homeostasis
Humans
Neurochemistry
Neurology
Neurosciences
Original Paper
Receptors, Glutamate - physiology
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Summary:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key players in the mechanisms of neuronal cell death. Many research groups have been actively pursuing to establish a link between the deregulation of intracellular Ca 2+ homeostasis associated with excitotoxicity and calpain activity. It is well established that these two events are connected and interact synergistically to promote neurodegeneration, but whether calpain activity depends on or contributes to Ca 2+ deregulation is still under debate.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-010-0323-z