Prevalence of a Streptococcal Inhibitor of a Complement-Mediated Cell lysis-like Gene (sicG) in Streptococcus Dysgalactiae subsp. Equisimilis

Streptococcus dysgalactiae subsp. equisimilis isolates (n = 110) were analyzed by PCR to determine whether the gene encoding SICG, a homolog of Streptococcus pyogenes SIC, was present. Nineteen strains (17%) had this gene of which 11 (55%) were isolated from patients with invasive disease. All 19 st...

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Bibliographic Details
Published in:Current microbiology 2011-03, Vol.62 (3), p.884-887
Main Authors: Minami, Masaaki, Ichikawa, Mariko, Matsui, Hideyuki, Hata, Nanako, Wakiyama, Naoki, Matsumoto, Masakado, Ohta, Michio, Hasegawa, Tadao
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Bacterial - genetics
Bacterial Outer Membrane Proteins - genetics
Bacterial proteins
Bacterial Proteins - genetics
Biomedical and Life Sciences
Biotechnology
Carrier Proteins - genetics
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Genotype & phenotype
Humans
Life Sciences
Microbiology
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Alignment
Sequence Analysis, DNA
Streptococcus - genetics
Streptococcus dysgalactiae
Streptococcus infections
Streptococcus pyogenes
Virulence Factors - genetics
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Summary:Streptococcus dysgalactiae subsp. equisimilis isolates (n = 110) were analyzed by PCR to determine whether the gene encoding SICG, a homolog of Streptococcus pyogenes SIC, was present. Nineteen strains (17%) had this gene of which 11 (55%) were isolated from patients with invasive disease. All 19 strains possessed group G carbohydrate. Molecular characterization of emm type revealed that the majority of emm sequences were stG643 and stG2078. Only the N-terminal sequence of SICG was similar to that of SIC in S. pyogenes. Although we found no significant relationship between pathogenic severity and sicG possession, further investigation into the mechanism of SICG may elucidate the virulence in S. dysgalactiae subsp. equisimilis infection.
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-010-9798-8