An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China

Abstract During investigations into an outbreak of egg production decline, retarded growth, and even death among ducks in Southeast China, a novel Tembusu virus strain named Tembusu virus Fengxian 2010 (FX2010) was isolated. This virus replicated in embryonated chicken eggs and caused embryo death....

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2011-08, Vol.417 (1), p.1-8
Main Authors: Yan, Pixi, Zhao, Youshu, Zhang, Xu, Xu, Dawei, Dai, Xiaoguang, Teng, Qiaoyang, Yan, Liping, Zhou, Jiewen, Ji, Xiwen, Zhang, Shumei, Liu, Guangqing, Zhou, Yanjun, Kawaoka, Yoshihiro, Tong, Guangzhi, Li, Zejun
Format: Article
Language:English
Subjects:
Animals
Cercopithecus aethiops
Chick Embryo
China - epidemiology
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - veterinary
Communicable Diseases, Emerging - virology
Disease Outbreaks - veterinary
DNA, Viral - chemistry
Duck disease
Ducks
Emergence
Fibroblasts - virology
Flavivirus
Flavivirus - classification
Flavivirus - genetics
Flavivirus - pathogenicity
Flavivirus Infections - epidemiology
Flavivirus Infections - veterinary
Flavivirus Infections - virology
Infectious
Infectious Disease
Japanese encephalitis virus
Mice
Mice, Inbred BALB C
Phylogeny
Poultry Diseases - epidemiology
Poultry Diseases - virology
Specific Pathogen-Free Organisms
Tembusu virus
Vero Cells
Virus Replication
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Summary:Abstract During investigations into an outbreak of egg production decline, retarded growth, and even death among ducks in Southeast China, a novel Tembusu virus strain named Tembusu virus Fengxian 2010 (FX2010) was isolated. This virus replicated in embryonated chicken eggs and caused embryo death. In cross-neutralization tests, antiserum to the partial E protein of Tembusu virus Mm1775 strain neutralized FX2010, whereas antiserum to Japanese encephalitis virus did not. FX2010 is an enveloped RNA virus of approximately 45–50 nm in diameter. Sequence analysis of its E and NS5 genes showed that both genes share up to 99.6% nucleotide sequence identity with Baiyangdian virus, and up to 88% nucleotide sequence identity with their counterparts in Tembusu virus. FX2010 was transmitted without mosquito, and caused systemic infection and lesions in experimentally infected ducks. These results indicate that FX2010 and BYD virus are newly emerged Tembusu virus strains that cause an infectious disease in ducks.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2011.06.003