Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE)

Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Usin...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2011-08, Vol.459 (2), p.221-226
Main Authors: Veits, Lothar, Mechtersheimer, Gunhild, Steger, Christina, Freitag, Jens, Mikuz, Gregor, Schmid, Kurt W., Hofmann, Walter, Schirmacher, Peter, Hartmann, Arndt, Rieker, Ralf J.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chromosome Aberrations
Comparative Genomic Hybridization
Female
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Thymoma - genetics
Thymoma - pathology
Thymus Neoplasms - genetics
Thymus Neoplasms - pathology
Thyroid
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Summary:Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-011-1117-7