Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure

Diacylglycerol kinase ζ (DGKζ) inhibited atrial tachyarrhythmias in a mouse model of heart failure (HF) in our study. However, whether DGKζ prevents the HF-induced ventricular tachyarrhythmia (VT) is unknown. Effects of DGKζ on VT using transgenic mice with transient cardiac expression of activated...

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Published in:Circulation journal : official journal of the Japanese Circulation Society 2011, Vol.75 (10), p.2333-2342
Main Authors: Hirose, Masamichi, Takeishi, Yasuchika, Niizeki, Takeshi, Nakada, Tsutomu, Shimojo, Hisashi, Kashihara, Toshihide, Horiuchi-Hirose, Miwa, Kubota, Isao, Mende, Ulrike, Yamada, Mitsuhiko
Format: Article
Language:English
Subjects:
Animals
Diacylglycerol Kinase - genetics
Diacylglycerol Kinase - physiology
GTP-Binding Protein alpha Subunits, Gq-G11 - genetics
Heart Failure - complications
Mice
Mice, Transgenic
Myocytes, Cardiac
Tachycardia, Ventricular - etiology
Tachycardia, Ventricular - prevention & control
TRPC Cation Channels
Ventricular Premature Complexes - etiology
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Summary:Diacylglycerol kinase ζ (DGKζ) inhibited atrial tachyarrhythmias in a mouse model of heart failure (HF) in our study. However, whether DGKζ prevents the HF-induced ventricular tachyarrhythmia (VT) is unknown. Effects of DGKζ on VT using transgenic mice with transient cardiac expression of activated G protein α(q) (Gα(q)-TG; model of HF) were elucidated and double transgenic mice with cardiac-specific overexpression of both DGKζ and the activated Gα(q) (Gα(q)/DGKζ-TG) were used. Premature ventricular contraction (PVC) and/or VT were frequently observed in Gα(q)-TG mice but not in Gα(q)/DGKζ-TG and wild-type (WT) mice (P
ISSN:1347-4820