Epidermal Growth Factor―Like Domain 7 Is a Novel Inhibitor of Neutrophil Adhesion to Coronary Artery Endothelial Cells Injured by Calcineurin Inhibition

We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury. Human coronary endothelial cells...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2011-09, Vol.124 (11), p.S197-S203
Main Authors: BADIWALA, Mitesh V, GUHA, Daipayan, TUMIATI, Laura, JOSEPH, Jemy, GHASHGHAI, Arash, ROSS, Heather J, DELGADO, Diego H, RAO, Vivek
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Blood vessels and receptors
Calcineurin - drug effects
Calcineurin Inhibitors
Calcium-Binding Proteins - pharmacology
Cardiology. Vascular system
Cell Adhesion - drug effects
Cells, Cultured
Coronary Vessels - cytology
Cyclosporine - pharmacology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endothelial Growth Factors - pharmacology
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Immunosuppressive Agents - pharmacology
Intercellular Adhesion Molecule-1 - metabolism
Intercellular Signaling Peptides and Proteins - pharmacology
Jagged-1 Protein
Medical sciences
Membrane Proteins - pharmacology
Neutrophils - cytology
Neutrophils - drug effects
NF-kappa B - metabolism
Nitric Oxide - metabolism
Receptors, Notch - agonists
Serrate-Jagged Proteins
Signal Transduction - drug effects
Signal Transduction - physiology
Vertebrates: cardiovascular system
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Summary:We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury. Human coronary endothelial cells were incubated with cyclosporine (CyA) 10 μg/mL with or without Egfl7 (100 ng/mL) or the Notch receptor activator Jagged1 (200 ng/mL) for 6 to 48 hours. CyA upregulated nuclear factor-κB (p65) activity (128 ± 2% of control, P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.110.011734