Acute hepatitis C in Brazil: Results of a national survey

The incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. The objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A qu...

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Bibliographic Details
Published in:Journal of medical virology 2011-10, Vol.83 (10), p.1738-1743
Main Authors: Ferreira, Adalgisa de Souza Paiva, Perez, Renata de Mello, Ferraz, Maria Lucia Gomes, Lewis-Ximenez, Lia Laura, Pereira, João Luis, de Almeida, Paulo Roberto Lerias, de Mattos, Angelo Alves
Format: Article
Language:English
Subjects:
acute hepatitis C
Adolescent
Adult
Aged
Aged, 80 and over
Alanine Transaminase - blood
Biological and medical sciences
Biomarkers - analysis
Brazil
Brazil - epidemiology
Cross Infection - epidemiology
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
HCV
Health Surveys
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C - transmission
Hepatitis C Antibodies - blood
Hepatitis C virus
Human viral diseases
Humans
Infectious diseases
Jaundice - epidemiology
Kidney Failure, Chronic - complications
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Renal Dialysis - adverse effects
Risk Factors
RNA, Viral
Sexually Transmitted Diseases, Viral
Treatment Outcome
Viral diseases
Virology
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Summary:The incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. The objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A questionnaire was sent to all members of the Brazilian Society of Hepatology. Sixteen centers participated with a total of 170 cases between 2000 and 2008. Among them, 37 had chronic renal failure on hemodialysis and were evaluated separately. The main diagnostic criterion in non‐uremic patients was ALT (alanine aminotransferase) elevation associated with risk factors. In patients with chronic renal failure, anti‐hepatitis C virus (HCV) seroconversion was the most frequent criterion. Among the 133 non‐uremic patients the main risk factors were hospital procedures, whereas in hemodialysis patients, dialysis was the single risk factor in 95% of the cases. Jaundice was more frequent in non‐uremic patients (82% vs. 13%; P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.22175