Tumor‐to‐tumor metastasis: Hepatocellular carcinoma metastatic to parathyroid adenoma

Tumor‐to‐tumor metastasis is a rare, but well‐recognized phenomenon. Here, we report a unique case of hepatocellular carcinoma (HCC) metastatic to parathyroid adenoma. A 53‐year‐old‐man with a history of HCC presented with hypercalcemia. It was found that he also had hyperparathyroidism with a hypoe...

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Bibliographic Details
Published in:Pathology international 2011-10, Vol.61 (10), p.593-597
Main Authors: Lee, Hee Eun, Kim, Dong Hoon, Cho, Young Hye, Kim, Kyungeun, Chae, Seoung Wan, Sohn, Jin Hee
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Adenoma - therapy
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - secondary
Catheter Ablation - methods
Chemoembolization, Therapeutic - methods
hepatocellular carcinoma
Humans
Incidental Findings
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Male
Middle Aged
Neoplasm Metastasis
parathyroid adenoma
Parathyroid Neoplasms - metabolism
Parathyroid Neoplasms - secondary
Parathyroid Neoplasms - therapy
Parathyroidectomy
tumor‐to‐tumor metastasis
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Summary:Tumor‐to‐tumor metastasis is a rare, but well‐recognized phenomenon. Here, we report a unique case of hepatocellular carcinoma (HCC) metastatic to parathyroid adenoma. A 53‐year‐old‐man with a history of HCC presented with hypercalcemia. It was found that he also had hyperparathyroidism with a hypoechoic mass in the lower portion of the right thyroid gland area. The patient underwent parathyroidectomy, and a mass measuring 1.5 × 1.0 cm was detected. Microscopic and immunohistochemical examination disclosed parathyroid adenoma with a focus of metastatic HCC. For the patient, it was the only distant metastasis revealed until the last follow‐up. To the best of our knowledge, this is the first reported case of tumor‐to‐tumor metastasis in which HCC is the donor.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02707.x