Natural products: An evolving role in future drug discovery

The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity in natural products, able to interact with many specific targets within the cell and indeed for many years have been source or inspiration for the majority of FDA approved drugs. The present rev...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2011-10, Vol.46 (10), p.4769-4807
Main Authors: Mishra, Bhuwan B., Tiwari, Vinod K.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacokinetics
Antineoplastic Agents, Phytogenic - pharmacology
Approved drugs
Biological and medical sciences
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Cardiovascular Agents - chemistry
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Cardiovascular Diseases - drug therapy
Clinical development
Communicable Diseases - drug therapy
Drug discovery
Drug Discovery - methods
Humans
Inflammation - drug therapy
Medical sciences
Metabolic Diseases - drug therapy
Miscellaneous
Natural products
Neoplasms - drug therapy
Nervous System Diseases - drug therapy
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
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Summary:The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity in natural products, able to interact with many specific targets within the cell and indeed for many years have been source or inspiration for the majority of FDA approved drugs. The present review describes natural products (NPs), semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious (bacterial, fungal, parasitic and viral), immunological, cardiovascular, neurological, inflammatory and related diseases and oncology. Natural products have long been an excellent souces or inspiration for the drug development. This review describes natural and NP-derived compounds that have undergone clinical evaluation since past five years. [Display omitted] ► Medicinal plants have long been an excellent source of pharmaceutical agents. ► NP scaffolds are infact key in optimizing chemical diversity for human use. ► This review deals the clinical evaluation of 232 NP or their inspired drug candidates.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2011.07.057