Raman spectroscopy: a potential tool for early objective diagnosis of neoplasia in the oesophagus

There is a profound clinical need for a diagnostic tool that will enable clinicians to identify early neoplastic change in the oesophagus. Raman Spectroscopy (RS) has demonstrated the potential to provide non‐invasive, rapid, objective diagnosis of endoscopically invisible precancerous oesophageal d...

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Bibliographic Details
Published in:Journal of biophotonics 2011-10, Vol.4 (10), p.685-695
Main Authors: Almond, L. Max, Hutchings, Joanne, Shepherd, Neil, Barr, Hugh, Stone, Nick, Kendall, Catherine
Format: Article
Language:English
Subjects:
Barrett Esophagus - diagnosis
Barrett Esophagus - pathology
Barrett's oesophagus
dysplasia
Early Diagnosis
endoscopy
Endoscopy - instrumentation
Endoscopy - methods
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - pathology
Humans
Raman spectroscopy
Risk Factors
Spectrum Analysis, Raman - instrumentation
Spectrum Analysis, Raman - methods
vibrational spectroscopy
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Summary:There is a profound clinical need for a diagnostic tool that will enable clinicians to identify early neoplastic change in the oesophagus. Raman Spectroscopy (RS) has demonstrated the potential to provide non‐invasive, rapid, objective diagnosis of endoscopically invisible precancerous oesophageal dysplasia in vitro. RS analyses biological material to identify highly specific biochemical information that can be used to influence clinical care. Raman spectroscopic mapping could provide automated assessment of tissue biopsies to aid histopathological diagnosis in vitro. Furthermore, the recent development of fibre‐optic Raman probes has enabled endoscopic assessment of oesophageal mucosa in vivo. Accurate identification of dysplasia will enable targeted endoscopic resection of early lesions preventing the development of oesophageal cancer. This review summarises the development of Raman systems for use as laboratory based analytical adjuncts and endoscopic diagnostic tools in the distal oesophagus. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.201100041