Tendinopathy and Inflammation: Some Truths

Overuse tendinopathies are a common cause of pain and disability in athletes. According to histological findings, it is a “failed healing response” to overuse tendon injury. In obesity, macrophages and mast cells migrate to adipose tissue, and the resulting decreased availability of immune circulati...

Full description

Saved in:
Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2011-01, Vol.24 (1_suppl2), p.45-50
Main Authors: Del Buono, A., Battery, L., Denaro, V., Maccauro, G., Maffulli, N.
Format: Article
Language:English
Subjects:
Cumulative Trauma Disorders - pathology
Diabetes Mellitus, Type 1 - pathology
Diabetes Mellitus, Type 2 - pathology
Humans
Inflammation - etiology
Inflammation - pathology
Insulin Resistance - physiology
Obesity - complications
Tendinopathy - etiology
Tendinopathy - pathology
Tendon Injuries - etiology
Tendon Injuries - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Overuse tendinopathies are a common cause of pain and disability in athletes. According to histological findings, it is a “failed healing response” to overuse tendon injury. In obesity, macrophages and mast cells migrate to adipose tissue, and the resulting decreased availability of immune circulating cells should be responsible for less effective immune responses to acute tendon injury. In diabetic patients, free glucose molecules attach to collagen, alter collagen solubility, increase resistance to enzymatic degradation, and impair cross linking, contributing to the subsequent development of chronic tendinopathy secondary to a failed healing response to a tendon insult. Prolonged systemic, low-grade inflammation and impaired insulin sensitivity act as a risk factor for a “failed healing response” after an acute tendon insult, and predispose to the development of chronic overuse tendinopathies. Further studies may reveal novel therapeutic treatment approaches.
ISSN:0394-6320
2058-7384
DOI:10.1177/03946320110241S209