Surgical treatment of type 2 diabetes: the surgeon perspective

Type 2 diabetes mellitus (T2DM) is a major health priority globally, having achieved pandemic status in the twenty-first century. Several gastrointestinal procedures that were primarily designed to treat morbid obesity result in dramatic remission of diabetes. Studies in experimental rodent models a...

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Bibliographic Details
Published in:Endocrine 2011-10, Vol.40 (2), p.151-161
Main Authors: Shukla, Alpana P., Ahn, Soo Min, Patel, Rajesh T., Rosenbaum, Matthew W., Rubino, Francesco
Format: Article
Language:English
Subjects:
Animals
Bariatric Surgery - adverse effects
Bariatric Surgery - economics
Bariatric Surgery - trends
Cardiovascular Diseases - epidemiology
Cost-Benefit Analysis
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - economics
Diabetes Mellitus, Type 2 - surgery
Endocrinology
Health Care Costs
Humanities and Social Sciences
Humans
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Obesity - complications
Obesity - surgery
Obesity, Morbid - complications
Obesity, Morbid - surgery
Review
Risk Factors
Science
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Summary:Type 2 diabetes mellitus (T2DM) is a major health priority globally, having achieved pandemic status in the twenty-first century. Several gastrointestinal procedures that were primarily designed to treat morbid obesity result in dramatic remission of diabetes. Studies in experimental rodent models and humans have shown that the glycemic benefits of surgery are at least in part weight-independent and extend to non-morbidly obese subjects with T2DM. Bariatric procedures differ in their ability to ameliorate type 2 diabetes, with intestinal bypass procedures being more effective than purely restrictive procedures. Several studies have demonstrated that the benefits of bariatric surgery extend beyond amelioration of hyperglycemia and include improvement in other cardiovascular risk factors such as dyslipidemia and hypertension. The safety and cost-effectiveness of bariatric surgery are also well established by several studies. In this paper, the authors present the surgeon perspective on the management of type 2 diabetes focusing on the efficacy, safety and cost-effectiveness of metabolic surgery. The available evidence warrants the inclusion of metabolic surgery in the treatment algorithm of type 2 diabetes.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-011-9508-8