Room temperature ionic liquid-mediated molecularly imprinted polymer monolith for the selective recognition of quinolones in pork samples

A novel molecularly imprinted polymer monolith was prepared by the room temperature ionic liquid‐mediated in situ molecular imprinting technique, using norfloxacin (NOR) as the template, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross‐linker. The optimal synth...

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Bibliographic Details
Published in:Journal of separation science 2010-12, Vol.33 (23-24), p.3786-3793
Main Authors: Sun, Xiangli, He, Jia, Cai, Guorui, Lin, Anqing, Zheng, Wenjie, Liu, Xuan, Chen, Langxing, He, Xiwen, Zhang, Yukui
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - analysis
Biological and medical sciences
Chromatography, High Pressure Liquid
Columns (structural)
Crosslinking
Ethylene glycol
Extraction
Food industries
Fundamental and applied biological sciences. Psychology
Imprinted polymers
Ions
Meat and meat product industries
Meat Products - analysis
Microscopy, Electron, Scanning
Molecularly imprinted polymer monolith
Monomers
Polymers - chemistry
Pork samples
Quinolone antibiotics
Quinolones - analysis
Recognition
Room temperature ionic liquids
Selective recognition
Separation
Solid Phase Extraction - methods
Swine
Temperature
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Summary:A novel molecularly imprinted polymer monolith was prepared by the room temperature ionic liquid‐mediated in situ molecular imprinting technique, using norfloxacin (NOR) as the template, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross‐linker. The optimal synthesis conditions and recognition properties of NOR‐imprinted monolithic column were investigated. The results indicated that the imprinted monoliths exhibited good ability of selective recognition against the template and its structural analog. Using the fabricated material as solid‐phase extraction sorbent, a sample pre‐treatment procedure of molecularly imprinted solid‐phase extraction coupling with HPLC was developed for determination of trace quinolone residues in animal tissues samples. The recoveries ranging from 78.16 to 93.50% for eight quinolones antibiotics such as marbofloxacin, NOR, ciprofloxacin, danofloxacin, difloxacin, oxolinic acid, flumequine and enrofloxacin were obtained.
ISSN:1615-9306
1615-9314
1615-9314
DOI:10.1002/jssc.201000337