Bone-like forming ability of apatite–wollastonite glass ceramic

• Published in: Journal of the European Ceramic Society 2011-08, Vol.31 (9), p.1549-1561
• Main Authors: Magallanes-Perdomo, M., Luklinska, Z.B., De Aza, A.H., Carrodeguas, R.G., De Aza, S., Pena, P.
• Format: Article
• Language: English
• Subjects: Aluminum base alloys; Apatite; Biomedical applications; Dissolution; Eutectic composition; Glass; Glass ceramics; Simulated body fluid; Soaking; Surgical implants; Wollastonite-2 M
• ISSN: 0955-2219; 1873-619X
• DOI: 10.1016/j.jeurceramsoc.2011.03.007

This research describes the preparation, characterisation and in vitro behavior of a bioactive glass ceramic containing 44.8 wt% apatite, 28.0 wt% wollastonite-2 M and 27.2 wt% of amorphous phase. The biomaterial was obtained by a specific thermal cycle process that caused the devitrification of the Ca 3(PO 4) 2–CaSiO 3 binary system's stoichiometric eutectic composition. Overall, the material combines the properties of a resorbable Si–Ca-rich glass, in addition to bioactive properties of wollastonite and apatite phases. The bioactivity of this material was studied by soaking the samples in a simulated body fluid (SFB) for 3, 7, 14 and 21 days at 36.5 °C. During the soaking, the amorphous phase and also wollastonite-2 M phase underwent steady dissolution by releasing Si and Ca ions into the SBF medium. After 7 days, a porous hydroxy-carbonate apatite (HCA) layer was formed at the SBF–glass ceramic interface. The micro-nanostructured apatite–wollastonite-2 M glass ceramics with improved mechanical properties, in comparison with the parent glass, could serve as a promising platform for hard tissue regeneration.