Separation and characterization of gold nanoparticle mixtures by flow-field-flow fractionation

We show that using asymmetric flow-field-flow fractionation and UV–vis detector it is possible to separate, characterize, and quantify the correct number size distribution of gold nanoparticle (AuNP) mixtures of various sizes in the 5–60 nm range for which simple dynamic light scattering measurement...

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Bibliographic Details
Published in:Journal of Chromatography A 2011-07, Vol.1218 (27), p.4234-4239
Main Authors: Calzolai, Luigi, Gilliland, Douglas, Garcìa, César Pascual, Rossi, François
Format: Article
Language:English
Subjects:
AF4
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Detectors
Dynamic light scattering
Exact sciences and technology
Flow-field-flow fractionation
Fractionation
Gold
Light scattering
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Nanotoxicity
Other chromatographic methods
Separation
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Summary:We show that using asymmetric flow-field-flow fractionation and UV–vis detector it is possible to separate, characterize, and quantify the correct number size distribution of gold nanoparticle (AuNP) mixtures of various sizes in the 5–60 nm range for which simple dynamic light scattering measurements give misleading information. The size of the collected nanoparticles fractions can be determined both in solution and in the solid state, and their surface chemistry characterized by NMR. This method will find widespread applications both in the process of “size purification” after the synthesis of AuNP and in the identification and characterization of gold-based nanomaterials in consumer products.
ISSN:0021-9673
DOI:10.1016/j.chroma.2011.01.017