The endocrine regulation of aging in Caenorhabditis elegans

In recent years, there has been significant growth in our understanding of the regulation of longevity. The most notable change is the identification and detailed description of a number of molecular pathways modulating the rate of aging. A good portion of this new data has come from studies using t...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2009-02, Vol.299 (1), p.51-57
Main Authors: Kleemann, G.A., Murphy, C.T.
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
C. elegans
Caenorhabditis elegans - physiology
Communicating
Control
Endocrine
Endocrine System - physiology
Endocrinology
Exocrine Glands - physiology
Genetics
Insulin
Insulin - physiology
Insulin-Like Growth Factor I - physiology
Joining
Longevity
Mathematical models
Models, Biological
Modulation
Organisms
Signal Transduction - physiology
Steroids - physiology
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Description
Summary:In recent years, there has been significant growth in our understanding of the regulation of longevity. The most notable change is the identification and detailed description of a number of molecular pathways modulating the rate of aging. A good portion of this new data has come from studies using the genetic model organism Caenorhabditis elegans. In this review, we provide an overview of physiological systems that are involved in the modulation of aging in C. elegans, then discuss the known endocrine signaling systems that are likely to couple these systems together. Finally, we present a working model describing how aging may be regulated as a coordinated system, communicating through endocrine signals.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2008.10.048