Mechanotransduction at cadherin-mediated adhesions

Highlights ► The role of force at cell-to-cell junctions in development and disease. ► Recent advances in quantitative measurements of intercellular tension. ► Recent results demonstrating that cadherin complexes are tension sensors at cell-to-cell junctions. ► Recent findings indicate that alpha ca...

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Bibliographic Details
Published in:Current opinion in cell biology 2011-10, Vol.23 (5), p.523-530
Main Authors: Leckband, Deborah E, le Duc, Quint, Wang, Ning, de Rooij, Johan
Format: Article
Language:English
Subjects:
Animals
Cadherins - metabolism
Cell Adhesion
Cell-Matrix Junctions - metabolism
Extracellular Matrix - metabolism
Extracellular Matrix - physiology
Humans
Intercellular Junctions - metabolism
Internal Medicine
Mechanotransduction, Cellular
Signal Transduction
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Summary:Highlights ► The role of force at cell-to-cell junctions in development and disease. ► Recent advances in quantitative measurements of intercellular tension. ► Recent results demonstrating that cadherin complexes are tension sensors at cell-to-cell junctions. ► Recent findings indicate that alpha catenin is a tension sensor at cadherin-mediated cell–cell adhesions. ► Initial mechanistic studies implicating vinculin in the alpha-catenin-dependent force-transduction pathway at cadherin adhesions.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2011.08.003