Synthesis, characterization and anti-microbial studies of cadmium(II) compounds containing 3,10-C-meso-Me8[14]aneC. Crystal and molecular structure of cis-[CdLC(NO3)](NO3)

• Published in: Applied organometallic chemistry 2010-12, Vol.24 (12), p.878-887
• Main Authors: Roy, Tapashi G., Hazari, Saroj K. S., Barua, Kanak K., Anwar, Nurul, Zukerman-Schpector, Julio, Tiekink, Edward R. T.
• Format: Article
• Language: English
• Subjects: anti-bacterial activity; anti-fungal activity; cadmium(II); cis-compound; crystal structure; isomeric ligand; tetrazacyclotetradecane; trans-compound
• ISSN: 0268-2605; 1099-0739; 1099-0739
• DOI: 10.1002/aoc.1703

One isomeric ligand, LC, among three isomers of 3,10‐C‐meso‐3,5,7,7,10,12,14,14‐octamethyl‐1,4,8,11‐tetraazacyclotet‐radecanes (LA, LB and LC, differing in the orientation of methyl groups on the chiral carbon atoms), on reaction with Cd(NO3)2, CdCl2 and CdI2 produces octahedral cis‐mononitrato nitrate, trans‐dichloro and trans‐diiodo cadmium(II) compounds of formulae cis‐[CdLC(NO3)](NO3), trans‐[CdLCCl2] and trans‐[CdLCI2], respectively. The cis octahedral compound undergoes substitution reactions with KSCN, NaClO4 and KBr to form the trans‐substitution products, trans‐[CdLC(NCS)2], trans‐[CdLC(ClO4)2] and trans‐[CdLCBr2], respectively, whereby the bidentate NO3− ligand is replaced by two monodentate ligands that occupy axial positions. All compounds were characterized on the basis of analytical, spectroscopic, conductometric and magnetochemical data. The crystal structure of cis‐CdLC(NO3)](NO3) was determined by X‐ray crystallography and showed the cadmium centre to exist within a cis‐N4O2 donor set that defined a distorted octahedral geometry. Non‐systematic variations in the CdO and CdN bond distances were correlated with significant hydrogen bonding interactions operating in the crystal structure. The latter interactions led to the formation of supramolecular two‐dimensional arrays. The anti‐fungal and anti‐bacterial activities of these compounds were studied against some phytopathogenic fungi and bacteria. Coordination of LC by cadmium resulted in more effective anti‐microbial agents; no significant dependence upon the nature of the counter‐ion was detected. Copyright © 2010 John Wiley & Sons, Ltd. A series of cadmium(II) compounds with an isomeric N4‐donor macrocyclic ligand were thoroughly characterized. Several examples demonstrated significant anti‐fungal and anti‐bacterial activity.